Regular ArticleThe Effects of Muscarinic Cholinergic Receptor Blockade in the Rat Anterior Cingulate and Prelimbic/Infralimbic Cortices on Spatial Working Memory
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Dorsomedial prefrontal cortex and hippocampus represent strategic context even while simultaneously changing representation throughout a task session
2020, Neurobiology of Learning and MemoryCitation Excerpt :The prefrontal cortex (PFC) has long been thought to mediate executive function (Miller & Cohen, 2001; Dalley, Cardinal, & Robbins, 2004; Kesner & Churchwell, 2011) by participating in the storage and recall of contextual memories (Tronel & Sara, 2003; Euston, Gruber, & McNaughton, 2012; Preston & Eichenbaum, 2013) and maintaining that information in working memory (Ragozzino & Kesner, 1998; Delatour & Gisquest-Verrier, 1999; Cowen & McNaughton, 2007; Yoon, Okada, Jung, & Kim, 2008; Horst & Laubach, 2009; Urban, Layfield, & Griffin, 2014).
Telencephalic neurocircuitry and synaptic plasticity in rodent spatial learning and memory
2015, Brain ResearchCitation Excerpt :PL/IL has been shown to govern memory flexibly during reversal and extinction learning (Lacroix et al., 2002; Ragozzino, 2007; McDonald et al., 2008; Lattal et al., 2003; Delgado et al., 2008; Quirck and Mueller, 2008). Furthermore, PL/IL areas may also be important for working memory functions (Ragozzino et al., 1998; Ragozzino and Kesner, 1998; Kesner and Ragozzino, 2003). In contrast, the role of aCC remains unclear as some authors found aCC lesions to impair spatial learning (Warburton et al., 1998), whereas others did not (Sutherland et al., 1988; Teixeira et al., 2006; St-Laurant et al., 2009).
Cholinergic degeneration is associated with increased plaque deposition and cognitive impairment in APPswe/PS1dE9 mice
2013, Behavioural Brain ResearchAcetylcholine and attention
2011, Behavioural Brain ResearchCitation Excerpt :In short, studies that have used central administration of scopolamine do not provide a clear-cut picture of the role of the muscarinic system for each brain region. However, a rough differentiation can still be made; for instance, the cortical regions are involved in short-term memory functions [68–76], (conditional) discrimination [77–80], and conditioned taste aversion [81–83]. The amygdala and septohippocampal system appear necessary for anxiety-related behavior [84,85], and short-term memory [69,86–93].
The validity of scopolamine as a pharmacological model for cognitive impairment: A review of animal behavioral studies
2010, Neuroscience and Biobehavioral Reviews
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Address all correspondence and reprint requests to Dr. Raymond P. Kesner, Department of Psychology, University of Utah, Salt Lake City, Utah 84112. Fax: (801) 581-5841. E-mail:[email protected]. This research was supported by a grant from the National Institutes of Health (NS20771-12).