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Diffusion Tensor Imaging

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Book cover Magnetic Resonance Neuroimaging

Part of the book series: Methods in Molecular Biology ((MIMB,volume 711))

Abstract

Diffusion tensor MRI (DT-MRI) is the only non-invasive method for characterising the microstructural organization of tissue in vivo. Generating parametric maps that help to visualise different aspects of the tissue microstructure (mean diffusivity, tissue anisotropy and dominant fibre orientation) involves a number of steps from deciding on the optimal acquisition parameters on the scanner, collecting the data, pre-processing the data and fitting the model to generating final parametric maps for entry into statistical data analysis. Here, we describe an entire protocol that we have used on over 400 subjects with great success in our laboratory. In the ‘Notes’ section, we justify our choice of the various parameters/choices along the way so that the reader may adapt/modify the protocol to their own time/hardware constraints.

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Author information

Authors and Affiliations

  1. School of Psychology, Cardiff University Brain Research Imaging Centre (CUBRIC), Cardiff University, Cardiff, UK

    Derek K. Jones

  2. Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands

    Alexander Leemans

Authors
  1. Derek K. Jones
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  2. Alexander Leemans
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Corresponding author

Correspondence to Derek K. Jones .

Editor information

Editors and Affiliations

  1. Institute of Psychiatry, Department of Neuroscience, King's College London, Coldharbour Lane 125, London, SE5 9NU, United Kingdom

    Michel Modo

  2. Institute of Cell Engineering, Dept Radiology & Radiological Sciences, Johns Hopkins Univ. Sch. of Med., Rutland Ave. 720, Baltimore, 21205, Maryland, USA

    Jeff W.M. Bulte

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Jones, D.K., Leemans, A. (2011). Diffusion Tensor Imaging. In: Modo, M., Bulte, J. (eds) Magnetic Resonance Neuroimaging. Methods in Molecular Biology, vol 711. Humana Press. https://doi.org/10.1007/978-1-61737-992-5_6

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  • DOI: https://doi.org/10.1007/978-1-61737-992-5_6

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  • Publisher Name: Humana Press

  • Print ISBN: 978-1-61737-991-8

  • Online ISBN: 978-1-61737-992-5

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