Summary
Hypothermic responses to 5-HT1A receptor activation by the selective ligand ipsapirone (IPS) were attenuated in depressed patients as compared to controls. Chronic treatment with amitriptyline (AMI) further impaired 5-HT1Amediated hypothermia. The results indicate a subsensitive (presynaptic) 5-HT1A receptor and/or a defective post-receptor signalling pathway in depression and are consistent with the hypothesis that 5-HT1A receptors are down-regulted during AMI treatment.
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References
Anderson IM, Cowen PJ, Grahame-Smith DG (1989) Neuroendocrine and temperature effects of gepirone in humans. Br J Pharmacol 96: 3 P
Avery DH, Wildschiodtz G, Rafaelsen OJ (1982) Nocturnal temperature in affective disorder. J Affective Disord 4: 61–71
Goodwin GM, De Souza RJ, Green AR, Heal DJ (1987a) The pharmacology of the behavioural and hypothermic responses of rats to 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). Psychopharmacology 91: 506–511
Goodwin GM, De Souza RJ, Green AR (1987b) Attenuation by electroconvulsive shock and antidepressant drugs of the 5-HT1A receptor-mediated hypothermia and serotonin syndrome produced by 8-OH-DPAT in the rat. Psychopharmacology 91: 500–505
Green AR, Goodwin GM (1987) The pharmacology of the hypothermic response of rodents to 8-OH-DPAT administration and the effect of psychotropic drug administration on this response. In: Dourish CT, Ahlenius S, Hutson PH (eds) Brain 5-HT1A receptors. Ellis Horwood, Chichester, pp 161–176
Gudelsky GA, Koenig JI, Meltzer HY (1986) Thermoregulatory responses to serotonin (5-HT) receptor stimulation in the rat. Neuropharmacology 25: 1307–1313
Hutson PH, Donohoe TP, Curzon G (1987) Hypothermia induced by the putative 5-HT1A agonist LY 165163 and 8-OH-DPAT is not prevented by 5-HT depletion. Eur J Pharmacol 143: 121–128
Lesch KP, Mayer S, Hoh A, Disselkamp-Tietze J, Rupprecht R, Schmidtke A, Osterheider M, Beckmann H (1989a) 5-Hydroxytryptamine-1A (5-HT1A) receptor function in affective disorders. Pharmacopsychiatry 22: 205
Lesch KP, Poten B, Söhnle K, Schulte HM (1989b) The pharmacology of the hypothermic response to 5-HT1A receptor activation in humans. Eur J Clin Pharmacol (in press)
Lesch KP, Mayer S, Disselkamp-Tietze J, Hoh A, Schoellnhammer G, Schulte HM (1990) Subsensitivity of the 5-hydroxytryptamine1A (5-HT1A) receptor-mediated hypothermic response to ipsapirone in unipolar depression. Life Sci (in press)
Meltzer HY, Lowy MT (1987) The serotonin hypothesis of depression. In: Meltzer HY (ed) Psychopharmacology: the third generation of progress. Raven Press, New York, pp 513–526
Murphy DL, Mueller EA, Garrick NA, Aulakh CS (1986) Use of serotonergic agents in the clinical assessment of central serotonin function. J Clin Psychiatry 47: 9–15
Peroutka SJ (1988) 5-Hydroxytryptamine receptor subtypes: molecular, biochemical and physiological characterization. Trends Neurosci 11: 496–500
Spitzer RL, Endicott J, Robins E (1978) Research Diagnostic Criteria (RDC) for a selected group of functional disorders, 3rd edn. New York State Psychiatric Institute, New York
Traber J, Glaser T (1987) 5-HT1A receptor-related anxiolytics. Trends Pharmacol Sci 8: 432–437
Wozniak KM, Aulakh CS, Hill JL, Murphy DL (1988) The effect of 8-OH-DPAT on temperature in the rat and its modification by chronic antidepressant treatments. Pharmacol Biochem Behav 30: 451–456
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Lesch, K.P., Disselkamp-Tietze, J. & Schmidtke, A. 5-HT1A receptor function in depression: effect of chronic amitriptyline treatment. J. Neural Transmission 80, 157–161 (1990). https://doi.org/10.1007/BF01257081
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DOI: https://doi.org/10.1007/BF01257081