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Human drug metabolising cytochrome P450 enzymes: properties and polymorphisms

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Abstract

The cytochrome P450s are responsible for about 75% of phase I dependent drug metabolism and for the metabolism of a huge amount of dietary constituents and endogenous chemicals. The human has 59 active genes, and 6 of those encode important drug metabolising enzymes. About 40% of cytochrome P450 dependent drug metabolism is catalysed by polymorphic enzymes and such drug P450 interactions are frequently seen in adverse drug reaction reports. In this contribution an update of human cytochrome P450 enzymology and pharmacogenetics is given with particular emphasis on CYP1B1, CYP2B6, CYP2E1 and CYP3As.

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Acknowledgements

The work in the author’s laboratory is financed by the Swedish Research Council, The Swedish Cancer Society, AstraZeneca and by NIH (grant NIGMS 1-R01 GM60548–01A2).

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Correspondence to Magnus Ingelman-Sundberg.

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Ingelman-Sundberg, M. Human drug metabolising cytochrome P450 enzymes: properties and polymorphisms. Naunyn-Schmiedeberg's Arch Pharmacol 369, 89–104 (2004). https://doi.org/10.1007/s00210-003-0819-z

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