Abstract
Rationale
Given the hypothesised association between cannabis use and schizophrenia, and the well documented alterations in pre-pulse inhibition (PPI) that are observed in schizophrenia, it is of interest to examine the effects of cannabis use on PPI.
Objective
The objective of the study was to use novel methodology for the measurement and characterisation of attentional modulation of PPI, in order to examine the nature of PPI in chronic cannabis users.
Methods
PPI was measured in 34 chronic cannabis users (who were otherwise healthy) and 32 healthy controls, across a range of startling stimulus intensities, during two attention set conditions, one in which they were instructed to attend to the auditory stimuli and one in which they were instructed to ignore the auditory stimuli and focus on a visual task. Curves of best fit were fitted to the startle magnitudes, across the stimulus intensities. A number of reflex parameters were extracted from these logistic functions, each of which reflects a different characteristic of the startle response.
Results
Cannabis users failed to show attentional modulation of any of the reflex parameters and showed altered PPI, relative to controls, but only when they were instructed to sustain attention to the auditory stimuli.
Conclusion
Cannabis users showed an attention-dependant alteration in PPI, which appeared to reflect a deficit in sustain attention, and which was different to that which has been observed in schizophrenia using the same methodology.
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Acknowledgements
We gratefully acknowledge Peter Hackett and Rose Kwa for GCMS and CEDIA toxicology analyses.
Ethical standards
The experiment detailed in the current manuscript complied with the current laws in Australia.
Conflict of interest
Both KES and MTM-I declare no actual or potential conflicts of interest. Both authors have full control over all the data presented here, and agree to allow the journal to review the data if requested.
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Scholes, K.E., Martin-Iverson, M.T. Alterations to pre-pulse inhibition (PPI) in chronic cannabis users are secondary to sustained attention deficits. Psychopharmacology 207, 469–484 (2009). https://doi.org/10.1007/s00213-009-1679-0
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DOI: https://doi.org/10.1007/s00213-009-1679-0