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Impact of repetitive transcranial magnetic stimulation of the parietal cortex on metabolic brain activity: a 14C-2DG tracing study in the cat

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Abstract

Transcranial magnetic stimulation (TMS) is increasingly utilized in clinical neurology and neuroscience. However, detailed knowledge of the impact and specificity of the effects of TMS on brain activity remains unresolved. We have used 14C-labeled deoxyglucose (14C-2DG) mapping during repetitive TMS (rTMS) of the posterior and inferior parietal cortex in anesthetized cats to study, with exquisite spatial resolution, the local and distant effects of rTMS on brain activity. High-frequency rTMS decreases metabolic activity at the primary site of stimulation with respect to homologue areas in the unstimulated hemisphere. In addition, rTMS induces specific distant effects on cortical and subcortical regions known to receive substantial efferent projections from the stimulated cortex. The magnitude of this distal impact is correlated with the strength of the anatomical projections. Thus, in the anesthetized animal, the impact of rTMS is upon a distributed network of structures connected to the primary site of application.

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Acknowledgements

Sadly, since the initial submission of this manuscript, Prof. Bertram Payne passed away, and this paper is dedicated to his memory. The experimental work at Boston University School of Medicine was supported by NS32137 and NS47754 (BRP), and the personnel were supported by: “La Caixa” (Spain) and the Spanish Ministry of Science and Technology (AV-C); NS44624 (RJR); NSF (SGL); K24 RR018875, the National Alliance for Research in Schizophrenia and Depression and the Goldberg Fund (APL).

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Authors and Affiliations

  1. Cerebral Dynamics, Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, 02118, USA

    Antoni Valero-Cabré, Bertram R. Payne & Jarrett Rushmore

  2. Center for Non-invasive Brain Stimulation, Beth Israel Deaconess Medical Center, and Department of Neurology, Harvard Medical School, Boston, MA, 02215, USA

    Antoni Valero-Cabré & Alvaro Pascual-Leone

  3. Cerebral Systems Laboratory, School of Behavioral and Brain Sciences, University of Texas at Dallas, Richardson, TX, 75083, USA

    Stephen G. Lomber

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  1. Antoni Valero-Cabré
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  2. Bertram R. Payne
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  3. Jarrett Rushmore
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  4. Stephen G. Lomber
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  5. Alvaro Pascual-Leone
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Correspondence to Antoni Valero-Cabré.

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B.R. Payne has passed away since this paper was completed.

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Valero-Cabré, A., Payne, B.R., Rushmore, J. et al. Impact of repetitive transcranial magnetic stimulation of the parietal cortex on metabolic brain activity: a 14C-2DG tracing study in the cat. Exp Brain Res 163, 1–12 (2005). https://doi.org/10.1007/s00221-004-2140-6

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