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Amygdala responsiveness is modulated by tryptophan hydroxylase-2 gene variation

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Summary.

The tryptophan hydroxylase-2 gene (TPH2) codes for the enzyme of serotonin (5-HT) synthesis in the brain and variation of TPH2 has been implicated in disorders of emotion regulation. Here, we used functional magnetic resonance imaging (fMRI) to demonstrate that a potentially functional variant of TPH2 modulates amygdala responsiveness to emotional stimuli of both negative and positive valence.

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Authors and Affiliations

  1. Department of Psychology, Stony Brook University, Stony Brook, NY, USA

    T. Canli & E. Congdon

  2. Graduate Program in Genetics, Stony Brook University, Stony Brook, NY, USA

    T. Canli

  3. MRRC Yale University, New Haven, CT, USA

    R. T. Constable

  4. Molecular and Clinical Psychobiology, Department of Psychiatry and Psychotherapy, University of Würzburg, Würzburg, Germany

    L. Gutknecht & K. P. Lesch

Authors
  1. T. Canli
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  2. E. Congdon
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  3. L. Gutknecht
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  4. R. T. Constable
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  5. K. P. Lesch
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Canli, T., Congdon, E., Gutknecht, L. et al. Amygdala responsiveness is modulated by tryptophan hydroxylase-2 gene variation. J Neural Transm 112, 1479–1485 (2005). https://doi.org/10.1007/s00702-005-0391-4

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  • DOI: https://doi.org/10.1007/s00702-005-0391-4

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