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Associations between the serotonin-1A receptor C(-1019)G polymorphism and disordered eating symptoms in female adolescents

  • Biological Child and Adolescent Psychiatry - Original Article
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Abstract

The purpose of this study was to examine the relationship between the C(-1019)G polymorphism of the serotonin-1A receptor gene and eating behavior in female adolescents. A total of 204 post-menarche, adolescent women, aged 16–17 years, were recruited from two neighboring high schools in Seoul. Polymerase chain reaction (PCR) was used to isolate and examine the C(-1019)G polymorphism in the serotonin-1A receptor genes (rs6295) of all participants. The Bulimia Investigatory Test, Edinburgh (BITE) and the Eating Attitude Test-26 (EAT-26) were administered to all participants. The total score of the EAT-26 differed significantly among the three genotype groups [CC, CG, GG (F = 4.844, p = 0.009)]. Both the EAT-26 (F = 9.69, p = 0.002) and the BITE (F = 5.22, p = 0.023) scores were higher in the participants who were G allele carriers than in the non-carrier group. The dieting subscale of the EAT-26 was higher among the G allele carriers (F = 12.941, p < 0.001), and these results were maintained even after adjusting for depression and anxiety. These findings suggest that the C(-1019)G polymorphism in the 5-HT1A receptor gene is associated with disordered eating symptoms in Korean female adolescents.

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Authors and Affiliations

  1. Department of Psychiatry, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 108 Pyung-dong, Jongro-Gu, Seoul, Korea

    Se-Won Lim, Juwon Ha & Dong-Won Shin

  2. Department of Laboratory Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 108 Pyung-dong, Jongro-Gu, Seoul, Korea

    Hee-Yeon Woo

  3. Department of Obstetrics and Gynecology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 108 Pyung-dong, Jongro-Gu, Seoul, Korea

    Kye-Hyun Kim

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  1. Se-Won Lim
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  2. Juwon Ha
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Correspondence to Kye-Hyun Kim.

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S.-W. Lim and J. Ha contributed equally to the work.

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Lim, SW., Ha, J., Shin, DW. et al. Associations between the serotonin-1A receptor C(-1019)G polymorphism and disordered eating symptoms in female adolescents. J Neural Transm 117, 773–779 (2010). https://doi.org/10.1007/s00702-010-0412-9

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