Abstract
Using two independent datasets provided by National Institute of Health funded consortia, the Collaborative Programs for Excellence in Autism and Studies to Advance Autism Research and Treatment (n = 641) and the National Institute of Mental Health (n = 167), diagnostic validity and factor structure of the new Autism Diagnostic Interview (ADI-R) algorithms for toddlers and young preschoolers were examined as a replication of results with the 2011 Michigan sample (Kim and Lord in J Autism Dev Disord 42(1): 82-93, 2012). Sensitivities and specificities and a three-factor solution were replicated. Results suggest that the new ADI-R algorithms can be appropriately applied to existing research databases with children from 12 to 47 months and down to nonverbal mental ages of 10 months for diagnostic grouping.
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American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders: DSM-IV-TR (4th ed.). Washington, DC: Author.
Bishop, S., Guthrie, W., Coffing, M., & Lord, C. (2011). Convergent validity of the Mullen scales of early learning and the differential ability scales in children with autism spectrum disorders. American Journal on Intellectual and Developmental Disabilities, 116(5), 331–343.
Browne, M. W., & Cudeck, R. (1993). Alternative ways of assessing model fit. Testing Structural Equation Models, 154, 136–162.
Dawson, G., Rogers, S., Munson, J., Smith, M., Winter, J., Greenson, J., et al. (2010). Randomized, controlled trial of an intervention for toddlers with autism: the early start Denver model. Pediatrics, 125(1), 17–23.
Elliott, C. D. (1990). DAS administration and scoring manual. San Antonio: Psychological Corporation.
Frazier, T. W., Youngstrom, E. A., Kubu, C. S., Sinclair, L., & Rezai, A. (2008). Exploratory and confirmatory factor analysis of the autism diagnostic interview-revised. Journal of Autism and Developmental Disorders, 38(3), 474–480. doi:10.1007/s10803-007-0415-z.
Gotham, K., Risi, S., Dawson, G., Tager-Flusberg, H., Joseph, R., Carter, A., et al. (2009). A replication of the autism diagnostic observation schedule (ADOS) revised algorithms. Journal of American Academy of Adolescent Psychiatry, 47(6), 642–651.
Gotham, K., Risi, S., Pickles, A., & Lord, C. (2007). The autism diagnostic observation schedule: Revised algorithms for improved diagnostic validity. Journal of Autism and Developmental Disorders, 37(4), 613–627. doi:10.1007/s10803-006-0280-1.
Kim, S. H., & Lord, C. (2010). Restricted and repetitive behaviors in toddlers and preschoolers with autism spectrum disorders based on the autism diagnostic observation schedule (ADOS). Autism Research, 3, 162–173.
Kim, S. H., & Lord, C. (2012). New autism diagnostic interview-revised algorithms for toddlers and young preschoolers from 12 to 47 months of age. Journal of Autism and Developmental Disorders, 42(1), 82–93.
Lord, C. (1995). Follow-up of two-year-olds referred for possible autism. Journal of Child Psychology and Psychiatry and Allied Disciplines, 36(8), 1365–1382.
Lord, C., Petkova, E., Hus, V., Gan, W., Lu, F., Martin, D. M., et al. (2012). A multisite study of the clinical diagnosis of different autism spectrum disorders. Archive of General Psychiatry, 69(3), 306–313.
Lord, C., Risi, S., DiLavore, P. S., Shulman, C., Thurm, A., & Pickles, A. (2006). Autism from 2 to 9 years of age. Archives of General Psychiatry, 63(6), 694–701. doi:10.1001/archpsyc.63.6.694.
Lord, C., Rutter, M., DiLavore, P. C., & Risi, S. (1999). Autism diagnostic observation schedule: Manual. Los Angeles: Western Psychological Services.
Lord, C., Storoschuk, S., Rutter, M., & Pickles, A. (1993). Using the ADI-R to diagnose autism in preschool children. Infant Mental Health Journal, 14(3), 234–252.
Luyster, R., Gotham, K., Guthrie, W., Coffing, M., Petrak, R., Pierce, K., et al. (2009). The autism diagnostic observation schedule-toddler module: A new module of a standardized diagnostic measure for autism spectrum disorders. Journal of Autism and Developmental Disorders, 39(9), 1305–1320. doi:10.1007/s10803-009-0746-z.
Mullen, E. M. (1995). Mullen scales of early learning (AGS ed.). Circle Pines: American Guidance Service.
Muthén, L. K., & Muthén, B. O. (2007). M-plus user’s guide, version 5. Los Angeles: Muthen and Muthen.
Ozonoff, S., Cook, I., Coon, H., Dawson, G., Joseph, R. M., Klin, A., et al. (2004). Performance on Cambridge neuropsychological test automated battery subtests sensitive to frontal lobe function in people with autistic disorder: Evidence from the collaborative programs of excellence in autism network. Journal of Autism and Developmental Disorders, 34(2), 139–150.
Risi, S., Lord, C., Gotham, K., Corsello, C., Chrysler, C., Szatmari, P., et al. (2006). Combining information from multiple sources in the diagnosis of autism spectrum disorders. Journal of the American Academy of Child and Adolescent Psychiatry, 45(9), 1094–1103. doi:10.1097/01.chi.0000227880.42780.0e.
Rutter, M., Le Couteur, A., & Lord, C. (2003). Autism diagnostic interview, revised. Los Angeles: Western Psych Services.
Shumway, S., Farmer, C., Thurm, A., Joseph, L., Black, D., & Golden, C. (2012) The ADOS calibrated severity score: Relationship to phenotypic variables and stability over time. Autism Research. May 24 (epub ahead of print), retrieved July, 6, 2012, from http://www.ncbi.nlm.nih.gov/pubmed/22628087. doi:10.1002/aur.1238.
Shumway, S., Thurm, A., Swedo, S. E., Deprey, L., Barnett, L. A., Amaral, D. G., et al. (2011). Brief report: Symptom onset patterns and functional outcomes in young children with autism spectrum disorders. Journal of Autism and Developmental Disorders, 41(12), 1727–1732.
Siegel, B., Vukicevic, J., Elliott, G. R., & Kraemer, H. C. (1989). The use of signal detection theory to assess DSM-III-R criteria for autistic disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 28(4), 542–548.
Snow, A. V., Lecavalier, L., & Houts, C. (2009). The structure of the autism diagnostic interview-revised: Diagnostic and phenotypic implications. Journal of Child Psychology and Psychiatry and Allied Disciplines, 50(6), 734–742. doi:10.1111/j.1469-7610.2008.02018.x.
Sutera, S., Pandey, J., Esser, E. L., Rosenthal, M. A., Wilson, L. B., Barton, M., et al. (2007). Predictors of optimal outcome in toddlers diagnosed with autism spectrum disorders. Journal of Autism and Developmental Disorders, 3(1), 98–107.
van Lang, N. D. J., Boomsma, A., Sytema, S., de Bildt, A. A., Kraijer, D. W., Ketelaars, C., et al. (2006). Structural equation analysis of a hypothesised symptom model in the autism spectrum. Journal of Child Psychology and Psychiatry and Allied Disciplines, 47(1), 37–44. doi:10.1111/j.1469-7610.2005.01434.x.
Ventola, P. E., Kleinman, J., Pandey, J., Barton, M., Allen, S., Green, J., et al. (2006). Agreement among four diagnostic instruments for autism spectrum disorders in toddlers. Journal of Autism and Developmental Disorders, 36(7), 839–847.
Wechsler, D. (1989). Wechsler Preschool and Primary Scale of Intelligence (Rev ed.). New York: The Psychological Corporation.
Wiggins, L. D., & Robins, D. L. (2008). Excluding the ADI-R behavioral domain improves diagnostic agreement in toddlers. Journal of Autism and Developmental Disorders, 38(5), 972–976.
World Health Organization. (1992). The ICD-IO classification of mental and behavioral disorders: Clinical descriptions and diagnostic guidelines. Geneva: Author.
Acknowledgments
We gratefully acknowledge the help of Kaite Gotham and Alice Kau as well as the families that participated in this research. This study was supported by National Institute of Mental Health (NIMH) R01MH066469, NIMH R25MH067723, National Institute of Health Intramural Research Program, NIMH, National Institute on Deafness and Other Communication Disorders, National Institute of Neurological Disorders and Stroke, and Eunice Kennedy Shriver National Institute of Child Health and Human Development. One of the authors, Catherine Lord, receives royalties for the ADI-R and ADOS; profits related to this study were donated to charity.
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Kim, S.H., Thurm, A., Shumway, S. et al. Multisite Study of New Autism Diagnostic Interview-Revised (ADI-R) Algorithms for Toddlers and Young Preschoolers. J Autism Dev Disord 43, 1527–1538 (2013). https://doi.org/10.1007/s10803-012-1696-4
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DOI: https://doi.org/10.1007/s10803-012-1696-4