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Relationship Between White Matter Integrity, Attention, and Memory in Schizophrenia: A Diffusion Tensor Imaging Study

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Abstract

Attention and memory deficits are among the most prominent cognitive disturbances observed in schizophrenia. It has been suggested that a disruption in anatomical connectivity between areas involved in attentional control might be responsible for these abnormalities. We used Diffusion Tensor Tractography and Color Stroop/Negative Priming(NP) paradigm to investigate integrity of the Cingulum Bundle(CB), the main white matter tract interconnecting these regions, and its relationship with executive functions in patients with schizophrenia and matched controls. The Fractional Anisotropy(FA), was calculated along the CB pathways, and correlated with reaction times for each Stroop item, and both Stroop, and NP effects. Patients with schizophrenia demonstrated decreased CB integrity and diminished NP effect, compared with controls, but both groups showed Stroop effect. For patients only, reaction times for every item, as well as for Stroop effect, correlated with left CB FA. These findings suggest that CB integrity disruptions might compromise the executive processes in schizophrenia.

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Acknowledgements

The authors would like to thank Nancy Maxwell for her administrative assistance. Additionally, we gratefully acknowledge the support of the National Alliance for Research on Schizophrenia and Depression (MK), the National Institute of Health (R03 MH068464-01 to MK, K05 MH070047 and R01 MH 50747 to MES, R01 MH 40799 to RWM and P41RR013218, National Center For Research Resources to RK), the Department of Veterans Affairs Merit Awards (MES, RWM), and the VA Research Enhancement Award Program (REAP to RWM/MES). This work is also part of the National Alliance for Medical Image Computing (NAMIC), funded by the National Institutes of Health through the NIH Roadmap for Medical Research, Grant U54 EB005149 (RK and Core Project: MES).

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Authors and Affiliations

  1. Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women’s Hospital, Harvard Medical School, 1249 Boylston Street, Boston, MA, 02215, USA

    M. Kubicki, S. Bouix, M. Dreusicke & M. E. Shenton

  2. Clinical Neuroscience Division, Laboratory of Neuroscience, Boston VA Healthcare System-Brockton Division, Department of Psychiatry, Harvard Medical School, Brockton, MA, USA

    M. Kubicki, M. Niznikiewicz, E. Connor, L. Ungar, P. G. Nestor, S. Bouix, R. W. McCarley & M. E. Shenton

  3. Surgical Planning Laboratory, MRI Division, Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

    R. Kikinis & M. E. Shenton

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  1. M. Kubicki
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Correspondence to M. Kubicki.

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Kubicki, M., Niznikiewicz, M., Connor, E. et al. Relationship Between White Matter Integrity, Attention, and Memory in Schizophrenia: A Diffusion Tensor Imaging Study. Brain Imaging and Behavior 3, 191–201 (2009). https://doi.org/10.1007/s11682-009-9061-8

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