Abstract
Bipolar disease features states of severe depression that usually fluctuate with at least one episode of intense elation or mania. It is a disorder that has been thought for some time to have a heritable component. The lifetime prevalence of bipolar disease in the general population is approximately 1%. In contrast, family studies have shown the approximate lifetime risk of a first-degree relative of a bipolar proband to be 5% to 10%. Moreover, studies of monozygotic twins show that their risk of contracting the disease is as much as 75 times greater than that for the general population. In addition, adoption studies have demonstrated that biological relatives of bipolar patients are substantially more likely to have the disorder than are adoptive relatives.
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References and Recommended Reading
Craddock N, Jones I: The genetics of bipolar disorder. J Med Genet 1999, 88:585–594.
Nurnberger JJ, Foroud T: Genetics of bipolar affective disorder. Curr Psychiatry Rep 2000, 2:147–157. A thorough review of bipolar genetics.
Kessler RC, McGonagle KA: Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results form the national comorbidity survey. Arch Gen Psychiatry 1994, 51:8–19.
Biederman JS, Faraone V: Parsing the association between bipolar, conduct, and substance use disorders: a familial risk analysis. Biol Psychiatry 2000, 48:1037–1044. A good review.
Bottlender R, Jager M: Suicidality in bipolar compared to unipolar depressed inpatients. Eur Arch Psychiatry Clin Neurosci 2000, 250:257–261.
Potash J, Kane H: Attempted suicide and alcoholism in bipolar disorder: clinical and familial relationships. Am J Psychiatry 2000, 157:2048–2050.
Tsuang MT, Faraone SV: The Genetics of Mood Disorders. Baltimore, MD: Johns Hopkins; 1990.
Craddock N, Jones I: Molecular genetics of bipolar disorder. Br J Psychiatry 2001, 178:128–133. A good article.
Kornberg J, Brown J: Evaluating the parent-of-origin effect in bipolar affective disorder. Is a more penetrant subtype transmitted paternally J Affect Disord 2000, 59:183–192.
Souery D, Van Gestel S: Tryptophan hydroxylase polymorphism and suicidality in unipolar and bipolar affective disorders: a multicenter association study. Biol Psychiatry 2001, 49:405–409.
Dunayevich E, Keck P: Prevalence and description of psychotic features in bipolar mania. Curr Psychiatry Rep 2000, 2:286–290. A good description of psychotic bipolar mania.
Potash J, Willour V: The familial aggregation of psychotic symptoms in bipolar disorder pedigrees. Am J Psychiatry 2001, 158:1258–1264.
Winokur G, Scharfetter C: Stability of psychotic symptomatology (delusions, hallucinations), affective syndromes, and schizophrenic symptoms (thought disorder, incongruent affect) over episodes in remitting psychoses. Eur Arch Psychiatry Neurol Sci 1985, 234:303–307.
Berrettini W: Are schizophrenic and bipolar disorders related? A review of family and molecular studies. Biol Psychiatry 2000, 48:531–538.
Taylor MA, Berenbaum SA: Are schizophrenia and affective disorder related? Preliminary data from a family study. Am J Psychiatry 1993, 150:278–285.
Bramon E, Sham P: The common genetic liability between schizophrenia and bipolar disorder: a review. Curr Psychiatry Rep 2001, 3:332–337.
Tabares-Seisdedos R, Balanza-Martinez V: Similar effect of family history of psychosis on Sylvian fissure size and auditory P200 amplitude in schizophrenic and bipolar subjects. Psychiatry Res 2001, 108:29–38.
Coryell W, Endicott J: A family study of bipolar II disorder. Br J Psychiatry 1984, 145:49–54.
Prusoff B, Weissman M: Psychiatric illness in relatives of probands with delusional depression. Psychopharmacol Bull 1984, 20:358–361.
Kendler KS, Pedersen N: The treated incidence of psychotic and affective illness in twins compared with population expectation: a study in the Swedish twin and psychiatric registries. Psychol Med 1996, 26:1135–1144.
Noga J, Vladar K: A volumetric magnetic resonance imaging study of monozygotic twins discordant for bipolar disorder. Psychiatry Res 2001, 106:25–34.
Mendlewicz J, Rainer JD: Adoption study supporting genetic transmission in manic-depressive illness. Nature 1977, 268:327–329.
Wender PH, Kety SS: Psychiatric disorders in the biological and adoptive families of adopted individuals with affective disorders. Arch Gen Psychiatry 1986, 43:923–929.
Risch N, Botstein D: A manic depressive history. Nature Genet 1996, 12:351–353.
Tsuang MT, Winokur G: Morbidity risks of schizophrenia and affective disorders among first-degree relatives of patients with schizophrenia, mania, depression and surgical conditions. Br J Psychiatry 1980, 137:497–504.
Gershon ES, Hamovit I: A family study of schizoaffective bipolar I, bipolar II, unipolar and normal control probands. Arch Gen Psychiatry 1982, 39:1157–1167.
Rice J, Reich T: The familial transmission of bipolar illness. Arch Gen Psychiatry 1987, 44:441–447.
Andreasen NC, Rice J: Familial rates of affective disorder: a report from the National Institute of Mental Health collaborative study. Arch Gen Psychiatry 1987, 44:461–469.
Pauls DL, Morton LA: Risks of affective illness among first-degree relatives of bipolar I old-order Amish probands. Arch Gen Psychiatry 2000, 49:703–708.
Maier W, Lichtermann D: Continuity and discontinuity of affective disorders and schizophrenia. Results of a controlled family study. Arch Gen Psychaitry 1993, 50:871–883.
Heun R, Maier W: The distinction of bipolar II disorder from bipolar I and recurrent unipolar depression: results of a controlled family study. Acta Psychiatrica Scandinavica 1983, 87:279–284.
Kendler KS, Karkowski LM: The structure of psychosis. Arch Gen Psychiatry 1998, 55:492–499.
Bertelsen A, Harvald B: A Danish twin study of manic-depressive disorders. Br J Psychiatry 1977, 130:330–351.
Torgersen S: Genetic factors in moderately severe and mild affective disorders. Arch Gen Psychiatry 1986, 43:222–226.
Kendler KS, Pedersen N: A pilot Swedish twin study of affective illness, including hospital- and population-ascertained subsamples. Arch Gen Psychiatry 1993, 50:699–706.
Cardno AG, Marshall EJ: Heritability estimates for psychotic disorders. Arch Gen Psychiatry 1999, 56:162–168.
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Taylor, L., Faraone, S.V. & Tsuang, M.T. Family, twin, and adoption studies of bipolar disease. Curr Psychiatry Rep 4, 130–133 (2002). https://doi.org/10.1007/s11920-002-0046-1
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DOI: https://doi.org/10.1007/s11920-002-0046-1