Folie acid deficiency and methyl group metabolism in rat brain: Effects of l-dopa
References (13)
- et al.
Biochem. Pharmacol
(1973) - et al.
Biochim. Biophys. Acta
(1971) - et al.
- et al.
J. Biol. Chem
(1951) - et al.
J. Pharmacol. Exp. Ther
(1970) - et al.
Clin. Pharmacol. Ther
(1971)
Cited by (62)
Serum binding folate receptor autoantibodies lower in autistic boys and positively-correlated with folate
2024, Biomedicine and PharmacotherapyDietary and genetic manipulations of folate metabolism differentially affect neocortical functions in mice
2013, Neurotoxicology and TeratologyCitation Excerpt :Folate levels directly influence the availability of S-adenosylmethionine (SAM), the primary methyl donor for most biological methylation reactions including enzymes involved in the synthesis and degradation of the catecholamines, serotonin, and acetylcholine (Chan et al., 2008; Mischoulon and Fava, 2002). Biochemical data in animals have confirmed that a folate deficient diet for as little as five weeks after weaning can alter brain levels of SAM (Ordonez and Wurtman, 1974), dopamine (Gospe et al., 1995), norepinephrine (Kronenberg et al., 2008), acetylcholine (Chan et al., 2008), and serotonin metabolites (Gospe et al., 1995; Kronenberg et al., 2008). Based on this evidence, it follows that cognitive and affective functions modulated by these transmitter systems should be affected by altered folate metabolism.
Increase in plasma homocysteine levels induced by drug treatments in neurologic patients
2005, Pharmacological ResearchAltered levels of S-adenosylmethionine and S-adenosylhomocysteine in the brains of L-isoaspartyl (D-aspartyl) O-methyltransferase-deficient mice
2002, Journal of Biological ChemistryCitation Excerpt :In fact, in a study of the use of AdoMet as an antidepressant for patients with chronic epilepsy, it was found that daily intravenous administration of AdoMet had no adverse effect on seizure frequency (49). On the other hand, the administration of folate, the levels of which are correlated with intracellular AdoMet levels in rat brain (53), can greatly aggravate seizure control in epilepsy patients (50) and in experimental animals (51, 52). Thus, orally (or intravenously) administered AdoMet would probably not mimic the effect we observe in the Pcmt1−/− mice, which is most likely an intracellular alteration of AdoMet/AdoHcy levels.
The effect of L-dopa administration and folate deficiency on plasma homocysteine concentrations in rats
1997, Journal of Nutritional Biochemistry
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Present address: Catedra de Fisiopatologia, Instituto de Medicina Experimental, Universidad Central de Venezuela, Caracas, Venezuela.