Original articleCerebrospinal fluid levels of kynurenine pathway metabolites in patients with eating disorders: Relation to clinical and biochemical variable
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2020, Journal of EthnopharmacologyCitation Excerpt :Tryptophan plays important roles in improving growth performance, modulating feed intake and lactation, enhancing anti-oxidative and immune functions (Li et al., 2016). It is reported that the low level of tryptophan are likely lead to weight loss, mood disturbances and cognitive impairment (Demitrack et al., 1995; Schmitt et al., 2016; Zhang et al., 2013a). The increased catabolism of tryptophan may also divert this essential amino acid away from protein synthesis leading to weight loss and muscle wasting (Iwagaki et al., 1995).
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2019, Clinical Nutrition ExperimentalCitation Excerpt :Low KYNA/KYN plasma ratios are associated with depression and anxiety. Moreover, dysfunction of TRP-KYN metabolism has been also involved in AN pathophysiology [14,17]. Interestingly, activation of HPA axis, increased plasmatic cortisol and inflammation are known to activate TRP-KYN metabolism, leading to little available TRP for serotonin synthesis, resulting in psychiatric (anxiety, depression) and gastrointestinal disorders (Fig. 2).
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2013, Journal of EthnopharmacologyCitation Excerpt :Other effects include weight loss, mood disturbances and cognitive impairment (Demitrack et al., 1995; Schmitt et al., 2006). In anorexia nervosa, underweight anorexic patients had the lower tryptophan levels which rose with weight normalization (Demitrack et al., 1995). The heightened catabolism of tryptophan via the kynurenine pathway may also divert this essential amino acid away from protein synthesis, thus leading to weight loss and muscle wasting (Iwagaki et al., 1995).
Cerebrospinal fluid kynurenic acid in male and female controls - Correlation with monoamine metabolites and influences of confounding factors
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