Brain 5-HT1A, 5-HT1D, and 5-HT2 Receptors in suicide victims

doi:10.1016/0006-3223(94)90044-2

Biological Psychiatry

Volume 35, Issue 7, 1 April 1994, Pages 457-463

https://doi.org/10.1016/0006-3223(94)90044-2 Get rights and content

Abstract

We report on 5-HT_1A, 5-HT_1D, and 5-HT₂ binding sites in 23 control subjects and 18 suicide victims subdivided according to the method of death and the previous existence of depressive symptoms. No difference in maximum binding (B_max) or binding affinity (K_d) was found between the control and overall suicide groups for the binding sites studied. The drug overdose subgroup showed, however, a significant decrease in the 5-HT_1A binding affinity, probably explained by the higher sensitivity of this binding site to the acute administration of tricyclic antidepressants. A significant decrease in 5-HT_1D binding affinity was also found in the depressed suicides, together with a significant decrease in the number of 5-HT_1D binding sites in the nondepressed suicides. Further studies should be carried out on the 5-HT_1D binding site as it might represent a new tool in the understanding of the depressive illness.

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^☆: This study was founded by grants from the Stohne Foundation, Centrala Försöksdjursnämnden and Gamla Tjänarinnor, the Swedish Society for Medicine, FIS (93/0318), Ministerio Español de Asuntos Exteriores and Fundación Margit y Folke Pehrzon.

¹: J.M. was supported by the Swedish Medical Research Council (B92-12X-08648-04B).

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Original articleBrain 5-HT1A, 5-HT1D, and 5-HT2 Receptors in suicide victims☆

Abstract

Brain Res

Brain Res

Neuropharmacology

Brain Res

Trends Neurosci

Neuropharmacology

Brain Res

Eur J Pharmacol

Eur J Pharmacol

Neurosci Lett

Brain Res

Biol Psychiatry

Brain Res

Eur J Pharmacol

Trends Neurosci

Anal Biochem

J Affective Disord

Biol Psychiatry

The rat 5-hydroxytryptamine 1B receptor is the species homologue of the human 5-hydroxytryptamine 1Dβ receptor

Mol Pharmacol

Unaltered number of brain serotonin uptake sites in suicide victims

J Psychopharmacol

Autoradiographic demonstration of increased serotonin 5-HT2 and b-adrenergic receptor binding sites in the brain of suicide victims

Arch Gen Psychiatry

Original article
Brain 5-HT_1A, 5-HT_1D, and 5-HT₂ Receptors in suicide victims☆

Autoradiographic demonstration of increased serotonin 5-HT₂ and b-adrenergic receptor binding sites in the brain of suicide victims