Excitation of neurons in the nucleus locus coeruleus by substance P and related peptides
Reference (29)
- et al.
Iontophoretic application of opiates to the locus coeruleus
Brain Research
(1977) - et al.
Regional distribution of substance P in the brain of the rat
Brain Research
(1976) - et al.
Noradrenergic neurons of the locus coeruleus: inhibition by epinephrine and activation by the α-antagonist piperoxane
Brain Research
(1976) - et al.
Mescaline and LSD: direct and indirect effects on serotonin-containing neurons in brain
Europ. J. Pharmacol.
(1973) Effects of substance P on functionally identified units in cat spinal cord
Brain Research
(1976)- et al.
Thyrotropin releasing hormone (TRH)-containing nerve terminals in certain brain stem nuclei and in the spinal cord
Neurosci. Lett.
(1975) - et al.
Evidence for the existence of substance P containing fibers in striatonigral and pallidonigral pathways in rat brain
Brain Research
(1977) - et al.
The effects of substance P other and peptides on spinal neurons of the frog
Brain Research
(1974) - et al.
Noradrenergic neurons: morphine inhibition of spontaneous activity
Europ. J. Pharmacol.
(1974) - et al.
Minireview: Substance P
Life Sci.
(1974)
Evidence for substance P in habenula-interpeduncular tract
Brain Research
Substance P excitation of cerebral cortical Betz cell
Brain Research
Inhibition of both noradrenergic and serotonergic neurons in brain by the α-adrenergic agonist clonidine
Brain Research
Differenzierung der Biologischen Activitat Von Elidoisin und Substanz-P Analogen in Affinitat und Wirk Affinitat am Isolierten Meerschweinchenileum und Vergleich mit Aktivitat am Ratten Colon
Experientia (Basel)
Cited by (158)
Substance P, NPY, CCK and their receptors in five brain regions in major depressive disorder with transcriptomic analysis of locus coeruleus neurons
2024, European NeuropsychopharmacologyActivation of Preoptic Tachykinin 1 Neurons Promotes Wakefulness over Sleep and Volatile Anesthetic-Induced Unconsciousness
2021, Current BiologyCitation Excerpt :One proposed mechanism for this enhanced wakefulness is substance-P-mediated activation of wake-promoting LC neurons, known to express tachykinin receptors.40 Indeed, local administration of substance P depolarizes LC neurons and increases firing rate.41 POA Tac1 projections to the LC, as well as the LH, TMN, vPAG, and VTA (Figure 6), provide a likely endogenous source of substance P to enhance wakefulness.
Neurokinin receptors in drug and alcohol addiction
2020, Brain ResearchCitation Excerpt :Also, activity of the NK1R in the septal nuclei regulates coping behavior during stress exposure and modulates the release of 5HT in this region (Ebner, 2008). For NE, NK1R signaling seems to facilitate the activity of NE neurons in the locus coeruleus (Guyenet and Aghajanian, 1977; Cheeseman et al., 1983; Ma and Bleasdale, 2002). Some evidence suggests that the NK3R also regulates 5HT and NE signaling.
Substance P and the Neurokinin-1 Receptor: The New CRF
2017, International Review of NeurobiologyCitation Excerpt :Intracranial SP infusion induces increased locomotion, and this is reversed by DA antagonism or 6-OH-DA lesions of dopamine cells (Kelley, Stinus, & Iversen, 1979). For NE function specifically, SP infusion into the locus coeruleus increases neuronal firing in this noradrenergic brainstem nucleus (Cheeseman, Pinnock, & Henderson, 1983; Guyenet & Aghajanian, 1977). In this nucleus, NK1Rs are expressed directly on NE neurons to influence their activity and output (Chen, Wei, Liu, & Rao, 2000).
Control of arousal through neuropeptide afferents of the locus coeruleus
2016, Brain ResearchCitation Excerpt :LC neurons contain the neurokinin-1 tachykinin receptor (NK1), a receptor for SP (Caberlotto et al., 2003; Hahn and Bannon, 1999; Maeno et al., 1993; Nakaya et al., 1994; Shults et al., 1984). SP increases LC discharge both in vivo and in vitro (Cheeseman et al., 1983; Guyenet and Aghajanian, 1977; Koyano et al., 1993; Olpe et al., 1987). SP is not tonically released onto the LC under normal conditions, as SP antagonist administration has no effect on basal LC discharge (Haddjeri and Blier, 2008).
Psychostimulants, antidepressants and neurokinin-1 receptor antagonists ('motor disinhibitors') have overlapping, but distinct, effects on monoamine transmission: The involvement of L-type Ca<sup>2+</sup> channels and implications for the treatment of ADHD
2014, NeuropharmacologyCitation Excerpt :This proposal is consistent with the finding that, unlike serotonin, GR 205171 prevented a stress-induced increase in extracellular noradrenaline in the prefrontal cortex of freely-moving rodents (Renoldi and Invernizzi, 2006; Ebner and Singewald, 2007). It also fits with evidence that arousing/stressful stimuli increase release of substance P in the region of the locus coeruleus (Ebner and Singewald, 2007), which increases the firing-rate of noradrenergic neurones projecting from this nucleus (Guyenet and Aghajanian, 1977). As discussed in detail elsewhere (Yan et al., 2009), a lack of functional NK1R would cause excessive noradrenergic transmission during low states of arousal, but a deficit in noradrenergic transmission as arousal increases.