Neurotensin: a neuronal pathway projecting from amygdala through stria terminalis
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Cited by (75)
Ionic and signaling mechanisms involved in neurotensin-mediated excitation of central amygdala neurons
2021, NeuropharmacologyCitation Excerpt :In mice, NT-immunoreactive cells are expressed in both CeL (Honkaniemi et al., 1990; Kim et al., 2017; McCullough et al., 2018; Shimada et al., 1989; Wray and Hoffman, 1983) and CeM (Kim et al., 2017; McCullough et al., 2018) regions. The neurotensinergic circuits project from the CeA to a variety of brain regions including the parabrachial nucleus of the pons (Ma et al., 2019; Moga and Gray, 1985a, b; Torruella-Suarez et al., 2020), the bed of the stria terminalis (Uhl and Snyder, 1979), the substantia nigra pars compacta (Vankova et al., 1992) and reticulata (Gonzales and Chesselet, 1990), the ventromedial (Inagaki et al., 1983) and lateral (Allen and Cechetto, 1995) hypothalamus, the ventral tegmental area (Ma et al., 2019; Woodworth et al., 2018) and the locus coeruleus (Ma et al., 2019). The extensive projections of neurotensinergic fibers to diverse brain regions further support that NT plays important modulatory roles in the brain.
Chemoarchitecture of the bed nucleus of the stria terminalis: Neurophenotypic diversity and function
2021, Handbook of Clinical NeurologyCitation Excerpt :The small 13-amino acid hypotensive peptide, neurotensin (Carraway and Leeman, 1973, 1975), is widely distributed in the CNS including the periventricular, paraventricular, and suprachiasmatic nuclei of the hypothalamus, central and medial amygdala, BNST, nucleus accumbens, thalamic nuclei, ventral tegmentum, specific dorsal raphe nuclei, locus coeruleus, parabrachial nucleus, and the nucleus of the solitary tract (Jennes et al., 1982). The BNST receives heavy NT innervation from the amygdala (Uhl and Synder, 1979) to implicate its transmitter roles in regulating BNST function. But importantly, approximately 80%–90% of the CRF-containing neurons in the BNST was found to coexpress NT (Shimada et al., 1989).
The role of intraamygdaloid neurotensin and dopamine interaction in conditioned place preference
2018, Behavioural Brain ResearchCitation Excerpt :AMY, prefrontal cortex and NAC receive NTergic fibers originating from VTA [7,33]. NTergic neurons of CeA project to the bed nucleus of the stria terminalis, substantia nigra and lateral hypothalamus [33–35]. The above mentioned findings strongly indicate the role of NT in reward related behaviour and suggest the possible effect of NT and DA interaction on reinforcement and memory consolidation.
Substance P and neurotensin in the limbic system: Their roles in reinforcement and memory consolidation
2018, Neuroscience and Biobehavioral ReviewsCitation Excerpt :Only a few NTergic neurons can be identified in the VP (Zahm and Heimer, 1988). NTergic efferents of the CeA project to the LH (Allen and Cechetto, 1995), to the BNST (Uhl and Snyder, 1979), to the SN (Gonzales and Chesselet, 1990; Seroogy et al., 1987) and to the retrorubral field (Gonzales and Chesselet, 1990). The MeA sends NTergic fibres to the VMH (Inagaki et al., 1983).
Neurotensin immunolabeling relates to sexually-motivated song and other social behaviors in male European starlings (Sturnus vulgaris)
2015, Behavioural Brain ResearchCitation Excerpt :NT and NT1 receptors (the only known avian NT receptor [13]) are highly co-localized with dopamine neurons in VTA [14–16]. Regions with dopaminergic projections are enriched with NT-containing neurons and NT1 receptors [17–20], including areas involved in sexually-motivated song in songbirds (reviewed below). Despite the close relationship between NT and dopamine in multiple brain regions central to motivation and vocal production, NT's role in vocal communication or other social behaviors is unclear.