Neurotensin self-injection in the ventral tegmental area
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Cited by (79)
Neurotensin in reward processes
2020, NeuropharmacologyDiversity in the lateral hypothalamic input to the ventral tegmental area
2019, NeuropharmacologyCitation Excerpt :This appears to be due to behavioural hyperactivation, which may correspond with the increase in extracellular dopamine measured in the NAc (Cador et al., 1986; Kalivas et al., 1983; Kalivas and Duffy, 1990; Patterson et al., 2015). Intra-VTA NTS is proposed to be rewarding as it supports self-administration (Glimcher et al., 1987), conditioned place preference (Rouibi et al., 2015) as well as LH self-stimulation reward (Kempadoo et al., 2013; Rompré and Gratton, 1993). Notably, the LHNTS to VTA projection is not the only source of NTS in the VTA.
Neural Circuit Motifs in Valence Processing
2018, NeuronCitation Excerpt :To spotlight one understudied neuropeptide of interest, consider neurotensin. Neurotensin is found in many different brain regions and circuits, and was initially implicated in reward processing, particularly with respect to midbrain dopamine neurons (Binder et al., 2001; Cador et al., 1986; Glimcher et al., 1984, 1987; Palacios and Kuhar, 1981). Indeed, photostimulation of LH neurotensin neuron terminals in the VTA robustly supported positive reinforcement (Kempadoo et al., 2013).
The role of intraamygdaloid neurotensin and dopamine interaction in conditioned place preference
2018, Behavioural Brain ResearchDetermination of neurotensin projections to the ventral tegmental area in mice
2018, NeuropeptidesCitation Excerpt :Pharmacologic Nts activates VTA DA neurons (Legault et al., 2002; Seutin et al., 1989; Sotty et al., 2000, 1998; St-Gelais et al., 2004; Werkman et al., 2000), thereby increasing DA release in the NA (Kalivas et al., 1983; Kalivas and Duffy, 1990; Sotty et al., 2000, 1998; Steinberg et al., 1995) that can modify goal directed behaviors. Indeed, intra-VTA Nts has been shown to suppress homeostatic and motivated feeding (Cador et al., 1986; Kelley et al., 1989), increase locomotor activity (Cador et al., 1986; Elliott and Nemeroff, 1986; Feifel and Reza, 1999; Kalivas et al., 1983; Kalivas and Duffy, 1990; Kalivas et al., 1981; Panayi et al., 2005; Steinberg et al., 1994) and support self-administration (Glimcher et al., 1987; Kempadoo et al., 2013; Rompre and Gratton, 1993), conditioned place preference (CPP) (Glimcher et al., 1984; Rouibi et al., 2015) and locomotor sensitization similar to addictive drugs (Elliott and Nemeroff, 1986; Kalivas and Duffy, 1990; Kalivas and Taylor, 1985; Voyer et al., 2017). Intriguingly, many of these behavioral effects are specific to the VTA because Nts administration outside of the VTA elicits different effects.
A portion of this work was presented at the Meeting of the Society for Neurosciences, 1983, abstract 35.6. The research was supported by PHS Grant MH-35740.
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Present address: Department of Psychology, University of Pennsylvania, Philadelphia, PA 19104, U.S.A.
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Present address: Department of Psychology, Concordia University, Montreal, Que., Canada.