Haloperidol rapidly increases the number of neurotensin mRNA-expressing neurons in neostriatum of the rat brain
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Cited by (64)
Neurotensin in the nucleus accumbens reverses dopamine supersensitivity evoked by antipsychotic treatment
2017, NeuropharmacologyCitation Excerpt :Second, neurotensin analogues are being investigated as potential antipsychotics (Boules et al., 2007). Finally, antipsychotic treatment elevates striatal levels of both neurotensin (Bissette et al., 1988; Govoni et al., 1980; Kinkead et al., 2000; See et al., 1995) and mRNA for the neurotensin precursor, proneurotensin (Merchant et al., 1994, 1992, 1991). Thus, here we evaluated the hypothesis that increasing neurotensin activity in the NAc attenuates antipsychotic-induced dopamine supersensitivity.
Endogenous neurotensin attenuates dopamine-dependent locomotion and stereotypy
2004, Brain ResearchCitation Excerpt :Interestingly, when SCH 23390 and haloperidol were co administered (N=3) prior to C/l-DOPA treatment, Nt mRNA expression was significantly reduced compared to C/l-DOPA alone, but still significantly greater than vehicle control. This may be due to an “unmasking” of the stimulatory effects of haloperidol on striatal Nt mRNA expression [35]. To investigate whether NT modulates l-DOPA-induced locomotor activity, DD mice were treated systemically (IP) with the neurotensin receptor (NTR-1) antagonist, SR 48692, prior to l-DOPA (50 mg/kg), and locomotor activity was recorded for 8 h. DD mice were treated IP with vehicle (N=8), SR 48692 (0.05 mg/kg, N=6), or SR 48692 (0.2 mg/kg, N=8) 15 min prior to l-DOPA (50 mg/kg, IP), and locomotor activity was recorded for 8 h (Fig. 4).
A highly sensitive and selective radioimmunoassay for the measurement of neurotensin
2000, Journal of Neuroscience Methods
This work was supported by the Department of Veterans Affairs Research Service and NIA Grant No. NS 20311. We are thankful for the neurotensin cDNA clone provided by Dr. Paul Dobner (University of Massachusetts). We are also thankful for the technical assistance provided by Cheryl Refsdal and Kimberly Donnell.