Short communicationNeuron-specific human glutamate transporter: molecular cloning, characterization and expression in human brain☆,☆☆
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2012, Journal of the Neurological SciencesCitation Excerpt :Synaptic glutamate is removed by cytoplasmic membrane protein known as excitatory amino acid transporters (EAATs). Nigral dopamine neurons have been reported to express EAATs [11]. A deficiency of EAATs has been associated with reduced glutathione (GSH) levels and increased oxidant levels, as well as neurodegeneration in the hippocampus at an advanced age [12].
The Mammalian Transporter Families
2008, Seldin and Giebisch's The KidneyDelayed post-ischemic administration of CDP-choline increases EAAT2 association to lipid rafts and affords neuroprotection in experimental stroke
2008, Neurobiology of DiseaseCitation Excerpt :This transport is executed by the five high-affinity, sodium-dependent plasma membrane glutamate transporters (EAATs; Seal and Amara, 1999). Among them, EAAT2 (GLT-1) (Pines et al., 1992; Shashidharan et al., 1994) is responsible for up to 90% of all glutamate transport in adult tissue (review in Robinson, 1999). In humans, one of the few drugs which has shown positive results in stroke is CDP-choline (Dávalos et al., 2002).
The Mammalian Transporter Families
2007, Seldin and Giebisch's The Kidney: Physiology & Pathophysiology 1-2Translational control of glial glutamate transporter EAAT2 expression
2007, Journal of Biological Chemistry
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The sequence data reported in this paper have been submitted to the GenBank data libraries under the accession no. U08989.
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This work was supported by NIH Grants NS-16871 (A.P.), AG06647 (J.H.M.); by a grant from the International Federation of Parkinson's Disease Societies (P.S.). G.W.H. is supported by Aaron Diamond Foundation and by Alexandrine and Alexander Sinsheimer Fund. T.M. was an exchange student under the auspices of Biomedical Exchange Program (BMEP) between the USA and Germany. We thank Nancy Archin for expert technical assistance, and Betsy Chalfin for editorial assistance.