Short communicationGlucocortcoids mediate the stress-induced extracellular accumulation of glutamate☆
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2021, Progress in Neuro-Psychopharmacology and Biological PsychiatryCitation Excerpt :Glial cells (primarily astrocytes) play a significant role in these alterations as they actively regulate glutamate signaling, by removing glutamate from the synaptic cleft and releasing gliotransmitters acting on NMDA receptors as well as by expressing metabotropic glutamate receptors. Animal studies document that stress exposure induce glutamate release in the hippocampus and PFC (Moghaddam, 1993; Moghaddam et al., 1994; Musazzi et al., 2010) and a consequent downregulation of NMDA receptors (Harvey et al., 2004). At the same time, NMDA receptor activation contributes to the stress-induced inhibition of adult hippocampal neurogenesis (Gould et al., 1997) and to the stress-induced dendritic reorganization of pyramidal cells (Christian et al., 2011; Martin and Wellman, 2011).
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This work was supported in part by PHS Awards MH48404 (BM), AGO6633 (RMS) and Department of VA National Center for PTSD.