Serotonin depletion decreases serotonin transporter mRNA levels in rat brain
References (10)
- et al.
The effect of chronic imipramine administration on the densities of 5-HT1A and 5-HT2 receptors and the abundancies of 5-HT receptor and transporter mRNA in the cortex, hippocampus and dorsal raphe of three strains of rat
Brain Res.
(1994) A role for 5-HT in the action of antidepressant drugs
J. Pharmacol. Exp. Ther.
(1990)- et al.
Effect of chronic treatment with selective monoamic oxidase inhibitors and specific 5-hydroxytryptamine uptake inhibitors on [3H]paroxetine binding to cerebral cortical membranes of the rat
Neuropharmacology
(1987) - et al.
Tianeptine decreases both serotonin transporter mRNA and binding sites in rat brain
Eur. J. Pharmacol. Mol. Pharmacol. Sect.
(1994) - et al.
Regional brain expression of serotonin transporter mRNA and its regulation by reuptake inhibiting antidepressants
Mol. Brain Res.
(1993)
Cited by (42)
Serotonin receptor gene (5-HT1A) modulates alexithymic characteristics and attachment orientation
2014, PsychoneuroendocrinologyCitation Excerpt :A study associating the serotonin transporter promoter region (5-HTTLPR) in serotonin transporter gene (5-HTT) with alexithymia (Kano et al., 2012) demonstrated that, compared with individuals carrying the SS/LS genotype, individuals with the LL genotype registered higher scores on Toronto Alexithymia Scale (TAS-20) which is a commonly used self-report instrument assessing alexithymic characteristics (Bagby et al., 1994). It is possible that the level of serotonin in the brain affects individuals’ alexithymic characteristics given that the significant association between 5-HTT gene and alexithymia and the link between the higher activity of 5-HTT and a higher serotonin uptake rate and lower serotonin level in synaptic cleft (Linnet et al., 1995; Meyer et al., 2004). The serotonin level in the brain is regulated not only by the serotonin transporter (Heils et al., 1996) but also by the serotonin receptor (Larisch et al., 2003; Le Francois et al., 2008; Trueta and Cercos, 2012).
An animal model of eating disorders associated with stressful experience in early life
2011, Hormones and BehaviorCitation Excerpt :Most of serotonin neurons innervated to the whole brain regions including the hippocampus are localized in the raphe nucleus. 5-HTT takes up serotonin from the synaptic cleft immediately after its release and ceases serotonin neurotransmission, and 5-HTT mRNA expression in the raphe has been reported to be altered by brain serotonin level (Linnet et al., 1995; Choi et al., 2003). Thus, it is likely that the decreased mRNA levels of 5-HTT in the raphe nucleus of our MS rats may be related with decreased serotonin levels in the hippocampus.
Adverse early life experience and social stress during adulthood interact to increase serotonin transporter mRNA expression
2009, Brain ResearchCitation Excerpt :The findings with antidepressant drug treatment are not consistent, however, as other studies have found that antidepressants either increase slc6a4 mRNA expression (Lopez et al., 1994) or have no effect (Burnet et al., 1994; Koed and Linnet, 1997; Linnet et al., 1995; Spurlock et al., 1994). However, the latter studies measured slc6a4 mRNA expression in whole brain homogenates using multiprobe oligonucleotide solution hybridization (Spurlock et al., 1994), midbrain homogenates using northern blot (Koed and Linnet, 1997; Linnet et al., 1995), or undefined regions of the midbrain raphe complex using in situ hybridization histochemistry (Burnet et al., 1994), and therefore would not have detected regional differences in slc6a4 mRNA expression. Social defeat decreased slc6a4 mRNA expression in specific rostrocaudal regions of the DRV of MS15 and AFR rats, relative to MS15 and AFR rats exposed to a novel cage control condition, and these effects were only observed in the mid-rostrocaudal and rostral sections of the DRV.
Applying Neuroimaging Ligands to Study Major Depressive Disorder
2008, Seminars in Nuclear Medicine