Oral contraceptives in premenstrual syndrome: A randomized comparison of triphasic and monophasic preparations
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Cited by (96)
Progesterone – Friend or foe?
2020, Frontiers in NeuroendocrinologyCitation Excerpt :In particular, low-dose CHCs containing anti-androgenic progestogens have been proven useful in women with PMDD (Lopez et al., 2012; Kim et al., 2015), but also see (Eisenlohr-Moul et al., 2017)). Trials investigating CHCs with androgenic progestogens, on the other hand, have been less successful (Freeman et al., 2012; Backstrom et al., 1992). A potential explanation for the discrepancy between clinical reports and the aforementioned RCTs could be that while women with PMDD experience symptom relief in the luteal phase, they respond negatively to progestogens at other phases of the cycle (Lundin et al., 2017).
Mood and physical symptoms improve in women with severe cyclical changes by taking an oral contraceptive containing 250-mcg norgestimate and 35-mcg ethinyl estradiol
2013, ContraceptionCitation Excerpt :This indicates that in a subgroup of women, a progestagen and estradiol, together and alone, seem to induce mood symptoms and that different types of progestagens affect mood differently [4]. A monophasic combination seems to induce less negative symptoms than a triphasic combination with less hormonal fluctuation over cycle, leading to a more mood-stabilizing effect [4,15]. Data have been contradictory regarding the effect of oral contraceptive treatment on mood, but in healthy women with no underlying mood disorder, most of the reports indicate a benefit [6,16].
Luteal phase dysphoric disorder and premenstrual syndrome
2009, Quaderni Italiani di Psichiatria