Right hemisphere dominance of different mismatch negativities

doi:10.1016/0013-4694(91)90064-B

Electroencephalography and Clinical Neurophysiology

Volume 78, Issue 6, June 1991, Pages 466-479

https://doi.org/10.1016/0013-4694(91)90064-B Get rights and content

Abstract

Auditory stimulus blocks were presented to 10 reading subjects. Each block consisted of 2 types of stimulus, standard (P = 90%) and deviant (P = 10%), delivered in a random order with short constant inter-stimulus intervals. The standard stimuli were 600 Hz, 80 dB SPL 50 msec sine wave bursts. In different blocks, the deviant stimuli differed from the standards either in frequency (650 Hz), intensity (70 dB) or duration (20 msec). Left- and right-ear stimulations were used in separate blocks. Event-related brain potentials (ERPs) were recorded with 16 electrodes over both hemispheres. All the different types of deviant stimuli elicited an ERP component called the mismatch negativity (MMN). The MMN was larger over the right hemisphere irrespective of the ear stimulated whereas the N1 component, elicited by both standards, and deviants, was larger over the hemisphere contralateral to the ear stimulated. The results provide further evidence for the view that the MMN reflects a neural mismatch process with a memory trace which automatically codes the physical features of the repetitive stimuli.

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Cited by (295)

Omission mismatch negativity of speech sounds reveals a functionally impaired temporal window of integration in schizophrenia
2021, Clinical Neurophysiology
We hypothesized that sensory memory associated with the temporal window of integration (TWI) would be impaired in patients with schizophrenia, an issue that had not been evaluated using omission mismatch negativity (MMN) of complex speech sounds. We aimed to assess the functional changes in auditory sensory memory associated with the TWI in patients with schizophrenia by investigating the effect of omission of complex speech stimuli on the MMN.
In total, 17 patients with schizophrenia and 15 control individuals participated in the study. The MMN in response to omission deviants of complex speech sounds was recorded, while the participants were instructed to ignore the series of speech sounds.
The MMN latency in patients with schizophrenia was significantly prolonged by deviant stimuli to omissions corresponding to the early and late parts of the temporal TWI. There were no significant group differences in the amplitude of the MMN to omissions at different time points across the TWI.
Our results suggested that sensory tracing function in patients with schizophrenia is impaired in the early and the later half of the TWI.
We showed that certain MMN abnormalities in patients with schizophrenia may be caused by an impaired TWI.
Mismatch-negativity (MMN) in animal models: Homology of human MMN?
2021, Hearing Research
Mismatch negativity (MMN) has long been considered to be one of the deviance-detecting neural characteristics. Animal models exhibit similar neural activities, called MMN-like responses; however, there has been considerable debate on whether MMN-like responses are homologous to MMN in humans. Herein, we reviewed several studies that compared the electrophysiological, pharmacological, and functional properties of MMN-like responses and adaptation-exhibiting middle-latency responses (MLRs) in animals with those in humans. Accumulating evidence suggests that there are clear differences between MMN-like responses and MLRs, in particular that MMN-like responses can be distinguished from mere effects of adaptation, i.e., stimulus-specific adaptation. Finally, we discuss a new direction for research on MMN-like responses by introducing our recent work, which demonstrated that MMN-like responses represent empirical salience of deviant stimuli, suggesting a new functional role of MMN beyond simple deviance detection.
Hierarchical timescales of statistical learning revealed by mismatch negativity to auditory pattern deviations
2018, Neuropsychologia
The amplitude of mismatch negativity (MMN) elicited following an unexpected sound reflects a pattern-violation signal that will increase with estimated precision. Precision is inversely related to environmental variance, and should be higher the longer that current regularities have been stable. However, MMN amplitude can be impacted by initial learning such that the relative probability of sounds when first encountered distorts the precision estimates later associated with those sounds. The present study tested the hypothesis that MMN to a pattern violation would be differentially sensitive to both local and global patterning within a sequence, depending on whether the sound was common or rare at sequence onset. Sound sequences consisted of two levels of nested regularity: (1) two tones alternated probabilities as the local standard (p = .875) and deviant (p = .125), and (2) these alternations occurred regularly across four blocks of 2.4 min (stable components) or twelve blocks of 0.8 min (unstable components). Sequences were delivered first in an unstable-stable (“increasing-stability”) and next a stable-unstable (“decreasing-stability”) structure, both inducing a violation to the regular block length at the transition between components. MMN to the tone initially heard as a common repeating standard when later heard as a deviant was not affected by stability of either local (tone probabilities) or global (block length) patterns, reaching equivalent amplitude in all components. In contrast, MMN amplitude to the tone initially heard as deviant was significantly impacted by both local and global pattern stability. MMN amplitude was larger in stable than unstable blocks only if they were heard first (decreasing-stability sequence), and was significantly smaller in both stable and unstable block types after a violation of regular block length. Results are interpreted as local MMN amplitude being “weighted down” by decreased precision in the global structure, but only for the first deviant encountered.
Visual mismatch response and fMRI signal adaptation correlate in the occipital-temporal cortex
2018, Behavioural Brain Research
Several electrophysiological studies found response differences to a given stimulus when it is repeated frequently as compared to when it occurs rarely in oddball sequences. Initially defined in acoustic perception, such difference also exists in the visual modality and is referred to as visual mismatch negativity (vMMN). However, the repetition of a stimulus also leads to the reduction of the blood oxygen-level dependent (BOLD) signal (fMRI adaptation, fMRIa) when compared to alternating stimuli in fMRI experiments. So far no study compared the vMMN to fMRIa within the same paradigm and participants. Here we tested the possible connection between fMRIa and vMMN in a visual oddball paradigm in two separate sessions, acquiring electrophysiological and neuroimaging data for real and false characters from the same participants. We found significant visual mismatch response (vMM) as well as fMRIa for both character types. Importantly, the magnitude of the vMM over the CP1 electrode cluster showed a significant correlation with the fMRIa within the letter form area, for real characters. This finding suggests that similar neural mechanisms are responsible for the two phenomena.
Low-level neural auditory discrimination dysfunctions in specific language impairment—A review on mismatch negativity findings
2017, Developmental Cognitive Neuroscience
In specific language impairment (SLI), there is a delay in the child’s oral language skills when compared with nonverbal cognitive abilities. The problems typically relate to phonological and morphological processing and word learning. This article reviews studies which have used mismatch negativity (MMN) in investigating low-level neural auditory dysfunctions in this disorder. With MMN, it is possible to tap the accuracy of neural sound discrimination and sensory memory functions. These studies have found smaller response amplitudes and longer latencies for speech and non-speech sound changes in children with SLI than in typically developing children, suggesting impaired and slow auditory discrimination in SLI. Furthermore, they suggest shortened sensory memory duration and vulnerability of the sensory memory to masking effects. Importantly, some studies reported associations between MMN parameters and language test measures. In addition, it was found that language intervention can influence the abnormal MMN in children with SLI, enhancing its amplitude. These results suggest that the MMN can shed light on the neural basis of various auditory and memory impairments in SLI, which are likely to influence speech perception.
Attention is required for canonical brain signature of prediction error despite early encoding of the stimuli
2023, PLoS Biology
Prediction error is a basic component of predictive-coding theory of brain processing. According to the theory, each stage of brain processing of sensory information generates a model of the current sensory input; subsequent input is compared against the model and only if there is a mismatch, a prediction error, is further processing performed. Recently, Smout and colleagues found that a signature of prediction error, the visual (v) mismatch negativity (MMN), for a fundamental property of visual input—its orientation—was absent without endogenous attention on the stimuli. This is remarkable because the weight of evidence for MMNs from audition and vision is that they occur without endogenous attention. To resolve this discrepancy, we conducted an experiment addressing 2 alternative explanations for Smout and colleagues’ finding: that it was from a lack of reproducibility or that participants’ visual systems did not encode the stimuli when attention was on something else. We conducted a similar experiment to that of Smout and colleagues. We showed 21 participants sequences of identically oriented Gabor patches, standards, and, unpredictably, otherwise identical, Gabor patches differing in orientation by ±15°, ±30°, and ±60°, deviants. To test whether participants encoded the orientation of the standards, we varied the number of standards preceding a deviant, allowing us to search for a decrease in activity with the number of repetitions of standards—repetition suppression. We diverted participants’ attention from the oriented stimuli with a central, letter-detection task. We reproduced Smout and colleagues’ finding of no vMMN without endogenous attention, strengthening their finding. We found that our participants showed repetition suppression: They did encode the stimuli preattentively. We also found early processing of deviants. We discuss various explanations why the earlier processing did not extend into the vMMN time window, including low precision of prediction.
Building on a previous PLOS Biology manuscript, this update article provides new evidence that canonical brain signatures of prediction error are only generated in the presence of attention to the visual stimuli, despite the fact that early brain encoding of the stimuli can be observed.

View all citing articles on Scopus

^☆: Supported by the Academy of Finland, the Emil Aaltonen Foundation, (Tampere, Finland), and the Väinö Tanner Foundation (Helsinski, Finland).

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Main articleRight hemisphere dominance of different mismatch negativities☆

Abstract

Event-related brain potentials and the perception of a phonetic continuum

Biol. Psychol.

Separability of different negative components of the event-related potential associated with auditory stimulus processing

Psychophysiology

Event-related brain potentials reflecting processing of relevant and irrelevant stimuli during selective listening

Psychophysiology

Is there a mismatch negativity (MMN) in the visual modality? (Commentary)

Behav. Brain Sci.

On short and long auditory stores

Psychol. Bull.

Evoked potentials correlates of stimulus deviance during wakefulness and sleep in cat - animal model of mismatch negativity

Electroenceph. clin. Neurophysiol.

Evoked potential correlates of a sensory mismatch process during sleep in cats

Subcortical evoked potential correlates of early information processing: mismatch negativity in cats

Cognitive psychophysiology: the endogenous components of the ERP

Auditory magnetic fields from the human cortex

Scand. Audiol.

Event-related potentials (ERPs) to interruptions of steady rhythm

Psychophysiology

Evoked potential correlates of signal recognition between and within modalities

Science

Auditory evoked potentials to unpredictable shifts in pitch

Psychophysiology

Human brain: left asymmetries in temporal speech region

Science

Interstimulus interval dependence of the auditory vertex response and its magnetic counterpart: implications for their neural generation

Electroenceph. clin. Neurophysiol.

Responses of the primary auditory cortex to pitch changes in a sequence of tone pips: neuromagnetic recordings in man

Neurosci. Lett.

Novel popout in vision. (Commentary)

Behav. Brain Sci.

Reactions of human auditory cortex to changes in tone duration

Hear. Res.

Visual short-term memory

Multi SQUID recordings of the human cerebral magnetic fields may give information about memory processes in the human brain

Europhys. Lett.

Frontal lobes and the regulation of arousal processes

The duration of a neuronal trace of an auditory stimulus as indicated by event-related potentials

Biol. Psychol.

Scalp distributions of event-related potentials: an ambiguity associated with analysis of variance models

Electroenceph. clin. Neurophysiol.

Processing negativity: an evoked-potential reflection of selective attention

Psychol. Bull.

In search of a short-duration memory trace of a stimulus in the human brain

Selective attention and stimulus processing: reflections in event-related potentials, magnetoencephalogram and regional cerebral blood flow

Neurophysiological basis of the echoic memory as suggested by event-related potentials and magnetoencephalogram

The orienting response theory: an integration of informational and energetical aspects of brain function

Implications of ERP data for psychological theories of attention

Biol. Psychol.

The role of attention in auditory information processing as revealed by event-related brain potentials

Behav. Brain Sci.

The N2 deflection of ERP and the orienting reflex

Early selective attention effects on the evoked potential. A critical review and reinterpretation

Biol. Psychol.

The N1 wave of the human electric and magnetic response to sound: a review and an analysis of the component structure

Psychophysiology

Early selective-attention effect reinterpreted

Acta Psychol. (Amst.)

Main article
Right hemisphere dominance of different mismatch negativities☆