Ascending projections of the cerebellar fastigial nucleus to the hippocampus, amygdala, and other temporal lobe sites: Evoked potential and histological studies in monkeys and cats

doi:10.1016/0014-4886(74)90118-6

Experimental Neurology

Volume 45, Issue 2, November 1974, Pages 268-287

https://doi.org/10.1016/0014-4886(74)90118-6 Get rights and content

Abstract

Direct anatomical connections from the fastigial nucleus of the cerebellum to numerous sites in the temporal lobe have been demonstrated in cats and monkeys by evoked potential and histological studies. Fastigial nucleus stimulation evoked responses bilaterally of short delay through an extensive rostral-caudal portion of the hippocampi, at focal sites in the basolateral amygdalae, and over the middle temporal gyri, indicating the existence of monosynaptic connections. The histological studies, for which the Nauta-Gygax method, Fink-Heimer procedure I, and cresylechtviolet staining were used, showed direct bilateral fastigial efferents coursing into the hippocampi (principally to cell field CA III), dentate gyri and subicular regions, into a focal site in the basolateral amygdalae, and into the temporal lobe neocortex. The findings reported herein suggest that the cerebellar fastigial nuclei through direct connections to the temporal neocortex and deep temporal lobe sites, can profoundly affect the function of the higher nervous system and behavior.

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¹: This study was supported in part by funds from the Ittleson Family Foundation, New York, NY. The authors wish to acknowledge the technical assistance of Charles J. Fontana and Mildred J. Kennedy.

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Ascending projections of the cerebellar fastigial nucleus to the hippocampus, amygdala, and other temporal lobe sites: Evoked potential and histological studies in monkeys and cats

Abstract

Brain Res.

Electroencephalogr. Clin. Neurophysiol.

Brain Res.

Exp. Neurol.

Exp. Neurol.

Exp. Neurol.

Cerebellar projections to limbic system

J. Neurophysiol.

Lesions of the fastigial nuclei in the rhesus monkey

Amer. J. Anat.

Isolated lesions of the fastigial nuclei in the cat

J. Comp. Neurol.

Electrical stimulation of the interior of the cerebellum in the cat

Amer. J. Anat.

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J. Comp. Neurol.

Some cerebellar influences on electrically-induced cerebral seizures

Epilepsia

Chronic stimulation of the cerebellar cortex in the therapy of epilepsies in the human

The effect of chronic cerebellar stimulation upon epilepsy in man

Trans. Amer. Neurol. Ass.

Neurophysiological evidence of vestibular projections to thalamus, basal ganglia, and cerebral cortex

The connections of the amygdala

J. Neurol. Neurosurg. Psychiat.

The selective silver-impregnation of degenerating axons and their synaptic endings in non-mammalian species

Le pedoncule cerebelleux superieur et les terminaisons recelles de la voie cerebello-thalamique. Etude anatomo-experimentale

Men. Acad. Med.

A thalamic mechanism of postural control

Int. J. Neurol.

Degeneration in the hypothalamic connections of the albino rat

J. Anat.

The fine structure of the mossy fiber endings in the hippocampus of the rabbit

J. Anat.