Short reportA calcium antagonist for the treatment of depressive episodes: Single case reports
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Cited by (31)
Antidepressant-like and memory-enhancing effects of the N-type calcium channel blocker ziconotide in rats
2020, Behavioural Brain ResearchCitation Excerpt :The influx of calcium into neurons and excessive glutamate release can exacerbate depressive symptoms [7]. Improved outcomes were observed when administering the calcium channel antagonists nimodipine and verapamil to patients suffering from major depression or bipolar manic-depressive disorders [8,9]. In addition, we previously reported that both single and long-term intrathecal administrations of ziconotide improved calcium-related neuropathological changes and attenuated memory impairments in a rat model of morphine withdrawal [10,11].
Dextromethorphan and Dextrorphan as Heuristic Rapid-Acting, Conventional, and Treatment-Resistant Antidepressants, with Substance Abuse Considerations
2016, Neuropathology of Drug Addictions and Substance Misuse Volume 3: General Processes and Mechanisms, Prescription Medications, Caffeine and Areca, Polydrug Misuse, Emerging Addictions and Non-Drug AddictionsDextromethorphan as a potential rapid-acting antidepressant
2011, Medical HypothesesCitation Excerpt :The sigma-1 receptor is related to major depression pathophysiology [41,42], and to antidepressant response [41] in animal models of depression [43,44] and in psychotic major depression [45,46]. The only case series of calcium channel blocker treatment of major depression revealed a clinically substantial antidepressant activity of nimodipine, with a 63% decline in Hamilton depression scores; all 10 subjects improved, with half achieving full remission [47]. The relation between serotonin transporter blockade and antidepressant activity is well known, especially in regard to selective serotonin reuptake inhibitors.
Neurotransmitters and signal transduction processes in bipolar affective disorders: A synopsis
2001, Journal of Affective DisordersEffects of (±)-kavain on voltage-activated inward currents of dorsal root ganglion cells from neonatal rats
1999, European NeuropsychopharmacologyEffects of the atypical antidepressant trimipramine on field potentials in the low Mg<sup>2+</sup> -model in guinea pig hippocampal slices
1998, European Neuropsychopharmacology