Elsevier

Journal of Affective Disorders

Volume 12, Issue 3, May–June 1987, Pages 267-274
Journal of Affective Disorders

Dieting and weight loss in volunteers increases the number of α2-adrenoceptors and 5-HT receptors on blood platelets without effect on [3H]imipramine binding

https://doi.org/10.1016/0165-0327(87)90037-1Get rights and content

Abstract

Platelet monoamine receptor binding was determined in normal male and female subjects before and at the end of a 2- to 3-week weight reducing diet (1200 kcal daily). Dieting was associated with an increase in platelet binding sites for both [3H]yohimbine and [125I]iodolysergic acid diethylamide (iodolLSD). The affinity at the platelet [125I]iodoLSD binding site was reduced. In contrast, [3H]imipramine binding was unchanged. These results have important implications for studies that employ platelet binding as a peripheral marker of neurotransmitter function in psychiatric illness.

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