Research reportAn analysis of memory dysfunction in major depression
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2015, Journal of Affective DisordersCitation Excerpt :Neurocognitive functional impairment is frequently observed among depressed patients, and is already included as a diagnostic criterion for major depressive disorder (MDD) in the Diagnostic and Statistical Manual of Mental Disorders, Fourth (DSM-IV) and Fifth Editions (DSM-5) (Gualtieri et al., 2006). Since many studies have replicated the findings of Rush and colleagues (Rush et al., 1983), showing that depressed patients have more impairment in neurocognitive function than healthy control groups, especially on effort-demanding tasks, attention, and memory (Backman and Forsell, 1994; Fava, 2003; Ilsley et al., 1995; Pelosi et al., 2000; Tancer et al., 1990). The Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study indicated that approximately 90% of 2541 MDD patients had difficulty with concentration and decision making (Gaynes et al., 2007; Nierenberg et al., 2010).