Interrelationships among anxiety, aggression, impulsivity, and mood: A serotonergically linked cluster?
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2018, Hormones and BehaviorCitation Excerpt :Much like the pattern observed in the hypothalami of males as compared to females, the male pituitary also had less differential gene expression than the female pituitary. For example, genes that increased in expression in the male pituitary in response to stress include Nuclear receptor subfamily 4 group A member 3 (NR4A3) (logFC -2.9, FDR 5.3e-10), which has been implicated in mechanisms related to feeding behavior and energy balance (Kim et al., 2013; Nonogaki et al., 2009), and 5-hydroxytryptamine receptor 3A (HTR3A) (logFC −1.9, 4.42e-05), a receptor whose ligand (serotonin) is widely accepted to be involved in mood disorder and anxiety (Apter et al., 1990; Bagdy, 1998; Millan, 2003; Nonogaki et al., 2009). A signal of cell-cycle arrest may be evident, as the gene CCAAT/enhancer binding protein (C/EBP), delta, know to be involved in preventing the cell cycle from continuing through the G1 phase (Johnson, 2005) increased in expression in response to stress (logFC −2.6, FDR 3.1e-09).
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