Elsevier

Psychiatry Research

Volume 42, Issue 2, May 1992, Pages 145-158
Psychiatry Research

Symptomatology and electrodermal activity as predictors of neuroleptic response in young male schizophrenic inpatients

https://doi.org/10.1016/0165-1781(92)90078-HGet rights and content

Abstract

This study examined whether the response to treatment with neuroleptic medication in 21 schizophrenic patients could be predicted from symptomatology, electrodermal activity, and premorbid adjustment. Positive symptoms and high levels of electrodermal activity were associated with a good response to conventional neuroleptic drugs. However, multivariate analysis indicated that symptomatology was the only independent predictor of treatment response.

References (48)

  • American Psychiatric Association

    DSM-III: Diagnostic and Statistical Manual of Mental Disorders

    (1980)
  • N.C. Andreasen et al.

    Positive and negative symptoms in schizophrenia

    Archives of General Psychiatry

    (1990)
  • M. Åsberg et al.

    The CPRS: Development and applications of a psychiatric rating scale

    Acta Psychiatrica Scandinavica

    (1978)
  • R.J. Baldessarini et al.

    Significance of neuroleptic dose and plasma level in the pharmacological treatment of psychoses

    Archives of General Psychiatry

    (1988)
  • A.S. Bernstein

    Orienting response research in schizophrenia: Where we have come and where we might go

    Schizophrenia Bulletin

    (1987)
  • W.A. Brown et al.

    Response to neuroleptic drugs as a device for classifying schizophrenia

    Schizophrenia Bulletin

    (1989)
  • T.D. Cannon et al.

    Third ventricle enlargement and reduced electrodermal responsiveness

    Psychophysiology

    (1988)
  • M.L. Clark et al.

    Chlorpromazine in chronic schizophrenia: The effect of age and hospitalization on behavioral dose-response relationships

    Archives of General Psychiatry

    (1972)
  • T.J. Crow

    Molecular pathology of schizophrenia: More than one disease process?

    British Medical Journal

    (1980)
  • J.G. Csernansky et al.

    Problems in classification of schizophrenics as neuroleptic responders and nonresponders

    Journal of Nervous and Mental Disease

    (1985)
  • R. Davila et al.

    Plasma homovanillic acid as a predictor of response to neuroleptics

    Archives of General Psychiatry

    (1988)
  • J.M. Davis et al.

    Important issues in the drug treatment of schizophrenia

    Schizophrenia Bulletin

    (1980)
  • T.R. Dening et al.

    Wilson's disease: Psychiatric symptoms in 195 cases

    Atchives of General Psychiatry

    (1989)
  • D.C. Fowles et al.

    Publication recommendations for electrodermal measurements

    Psychophysiology

    (1981)
  • Cited by (0)

    View full text