Research reportDevelopmental regulation of 5-HT2 and 5-HT1C mRNA and receptor levels
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Cited by (115)
Gene-environment interactions in antisocial behavior are mediated by early-life 5-HT<inf>2A</inf> receptor activation
2019, NeuropharmacologyCitation Excerpt :These results are in line with previous evidence indicating that ES leads to a selective up-regulation and activation of these receptors in the PFC (Benekareddy et al., 2010; Sood et al., 2018). In rodents, 5-HT2A receptor density in the brain is relatively low in the perinatal period, and estimated to reach only ∼20% of the levels observed in adults (Roth et al., 1991); however, the expression of these receptors increases progressively from P3 through the first three postnatal weeks (Li et al., 2004), and their activation in this period – and particularly at its beginning - is posited to promote the activation of pyramidal cells of the PFC (Béïque et al., 2004). Of note, 5-HT2A receptor antagonism during the first postnatal week attenuated aggression in GxE mice (as well as resting bradycardia in pups).
Ontogeny of monoamine neurotransmitters
2018, Handbook of Developmental NeurotoxicologySelective reduction of drebrin and actin in dendritic spines of hippocampal neurons by activation of 5-HT(2A) receptors.
2013, Neuroscience lettersCitation Excerpt :Particularly, the 5-HT2A receptor is a target of several hallucinogens, antipsychotics, anxiolytics, and antidepressants, and it is functionally and genetically associated with schizophrenia, autism, attention-deficit/hyperactivity disorder, and affective disorders [4,7,8,23,32,33]. The 5-HT2A receptors are expressed during late development stages, coinciding with a period of synapse formation [24], and localized to dendritic shafts and dendritic spines [12,15,19,22]. These observations suggest that the 5-HT2A receptors link synaptic morphogenesis and pathogenesis of psychiatric disorders.
A developmental characterization of mesolimbocortical serotonergic gene expression changes following early immune challenge
2010, NeuroscienceCitation Excerpt :The majority of these changes were transient, occurring during the third postnatal week (P14–P21). Given that 5-HT receptor expression reaches adult levels after P21 in rodents (Roth et al., 1991; Morilak and Ciaranello, 1993; Patel and Zhou, 2005), these results suggest that early immune challenge specifically targets developing 5-HT neurocircuitry. A few changes were observed at P28 which may reflect long-term alterations at the level of gene expression in particular 5-HT receptor sub-types.
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Present address: Geriatic Research and Education Clinical Center, Department of Psychiatry, University of Washington Medical School, Seattle, WA, U.S.A.