Detection of dynamic changes in cerebral oxygenation coupled to neuronal function during mental work in man

doi:10.1016/0304-3940(93)90094-2

Neuroscience Letters

Volume 150, Issue 1, 5 February 1993, Pages 5-8

https://doi.org/10.1016/0304-3940(93)90094-2 Get rights and content

Abstract

Changes in the oxygenation state of brain hemoglobin during mental work were monitored in real time (time resolution: 1 s) using near-infrared spectrophotometry in 14 healthy volunteers. In a younger group (age range 22–30 years, n = 12), the subjects finding difficulty in solving a problem were accompanied by significant increases in both oxygenated hemoglobin and total hemoglobin, while the subjects making a correct answer without difficulty showed no significant changes in hemoglobin oxygenation. When compared with those younger subjects, observations on the older subject demonstrated a decrease in oxygenated hemoglobin and a reciprocal increase in deoxygenated hemoglobin, unaccompanied by changes in total hemoglobin.

References (20)

J.E. Brazy
Near-infrared spectroscopy
A.R. Shah et al.
Fluctuations in cerebral oxygenation and blood volume during endotracheal suctioning in premature infants
J. Pediatr.
(1992)
S. Wray et al.
Characterization of the near infrared absorption spectra of cytochrome aa3 and haemoglobin for the non-invasive monitoring of cerebral oxygenation
Biochim. Biophys. Acta
(1988)
J.S. Wyatt et al.
Quantification of cerebral oxygenation and haemodynamics in sick newborn infants by near infrared spectrophotometry
Lancet
(1986)
J.E. Brazy et al.
Noninvasive monitoring of cerebral oxygenation in preterm infants: preliminary observation
Pediatrics
(1985)
C.B. Cairs et al.
A noninvasive method for monitoring the effects of increased intracranial pressure with near-infrared spectrophotometry
Surg. Gynecol. Obst.
(1985)
P.E. Fox et al.
Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects
F. Greenberg et al.
Localized metabolic flow couple during functional activity
Acta Neurol. Scand.
(1979)
O. Hazeki et al.
Quantitative analysis of hemoglobin oxygenation state of rat brain in situ by near-infrared spectrophotometry
J. Appl. Physiol.
(1988)
F.F. Jöbsis
Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters
Science
(1977)

There are more references available in the full text version of this article.

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Detection of dynamic changes in cerebral oxygenation coupled to neuronal function during mental work in man

Abstract

J. Pediatr.

Biochim. Biophys. Acta

Lancet

Noninvasive monitoring of cerebral oxygenation in preterm infants: preliminary observation

Pediatrics

A noninvasive method for monitoring the effects of increased intracranial pressure with near-infrared spectrophotometry

Surg. Gynecol. Obst.

Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects

Localized metabolic flow couple during functional activity

Acta Neurol. Scand.

Quantitative analysis of hemoglobin oxygenation state of rat brain in situ by near-infrared spectrophotometry

J. Appl. Physiol.

Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters

Science