Serotonin-, substance P- and glutamate/aspartate-like immunoreactivities in medullo-spinal pathways of rat and primate
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What substance P might tell us about the prognosis and mechanism of Parkinson's disease?
2021, Neuroscience and Biobehavioral ReviewsCitation Excerpt :In the brain, the main sites of SP immunoreactivity are in different areas, often lacking NK1-R: neocortex, limbic areas, habenula, periaqueductal gray matter and midbrain nuclei. High levels of SP/NK1-R immunoreactivity have been identified in hypothalamus, where SP frequently coexists with ‘classical’ neurotransmitters and neuropeptides (Dean et al., 1993; Ebner and Singewald, 2006; Hökfelt et al., 1982; Kachidian et al., 1991; Nicholas et al., 1992; Pickel, 1979). The presence of SP in the hypothalamic nuclei, involving the regulation of stress response and circadian rhythm, such as the paraventricular nucleus of the hypothalamus (PVN) and suprachiasmatic nucleus (SCN) (Ebner and Singewald, 2006), is congruent with neurobehavioral effects of SP, and the link between SP and the psychopathology of mood disorders (Herpfer and Lieb, 2003; Rosenkranz, 2007), and therefore with some non-motor symptoms reported by PD patients, including sleep disturbances, and depression.
Serotonin drives striatal synaptic plasticity in a sex-related manner
2021, Neurobiology of DiseaseCitation Excerpt :These findings proved that there is a unique monoaminergic mechanism controlling presynaptic inhibition of corticostriatal glutamate release and, in turn, prompted to investigate how DA and 5-HT systems may interact to influence striatum-dependent processes. This view is supported by the discovery that the raphe neurons, the main source of serotonergic fibers that project to almost all regions of the brain, are immunoreactive for glutamate and vesicular glutamate transporter 3 (VGLUT3) (Gras et al., 2002; Nicholas et al., 1992; Ottersen and Storm-Mathisen, 1984) as well as phosphate-activated glutaminase, an enzyme involved in the glutamate metabolism (Kaneko et al., 1990). Herein, we investigated the involvement of 5-HT in corticostriatal synaptic plasticity of striatal projection neurons (SPNs) recorded from male and female Tph2 knock-in mutant mice (Tph2GFP/GFP), which are depleted of brain 5-HT.
Substance P: A neuropeptide involved in the psychopathology of anxiety disorders
2020, NeuropeptidesCitation Excerpt :It is considered a key player in regulating the psychopathological conditions revealed by various experiments. It also acts as a neuromodulator in brain where it co-exists with various classical neurotransmitters such as glutamate, dopamine, GABA, acetylcholine, serotonin and noradrenaline depending upon the region of brain involved (Nicholas et al., 1992; Dean et al., 1993). SP is designted as the most abundantly found neurokinin peptide that is extensively distributed all over the nervous system (Quartara and Maggi, 1998; Severini, 2002).
5.15 - The Brainstem and Nociceptive Modulation
2020, The Senses: A Comprehensive Reference: Volume 1-7, Second EditionPreface
2020, Progress in Brain ResearchPotential involvement of serotonergic signaling in ketamine's antidepressant actions: A critical review
2016, Progress in Neuro-Psychopharmacology and Biological Psychiatry