Post-mortem drug redistribution — A toxicological nightmare
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Pharmacological data science perspective on fatal incidents of morphine treatment
2023, Pharmacology and TherapeuticsCitation Excerpt :In addition, RIA-derived concentrations should be disregarded because this historical method lacks specificity for morphine and therefore often results in falsely higher concentrations (Ferner, 2008; Yarema & Becker, 2005) and therefore have not been included in statistics and analyses of this article. Evidence of postmortem de-glucuronidation of M3G and M6G to morphine (Logan et al., 1997; Pounder & Jones, 1990; Prouty & Anderson, 1990; Skopp, 2004) or of postmortem increase or decrease of morphine concentrations in blood calls into question the reliability of above-mentioned morphine concentrations measured postmortem in a forensic medical context in which the causality of morphine dosing with and culpability for a patient's death is at issue. This has prompted several studies on changes in concentrations of morphine and its metabolites after death and on the interpretation of concentrations measured in exhumed material.
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