Original articleSerotonin transporter binding sites and mRNA levels in depressed persons committing suicide
References (54)
- et al.
Localized alterations in pre- and postsynaptic serotonin binding sites in the ventrolateral prefrontal cortex of suicide victims
Brain Res
(1995) - et al.
Reversed hemispheric asymmetry of imipramine binding in suicide victims
Biol Psychiatry
(1991) - et al.
[3H]Imipramine binding in the frontal cortex of suicides
Psychiatry Res
(1989) - et al.
Neurotransmitter receptors and monoamine metabolites in the brains of patients with alzheimer-type dementia and depression, and suicides
Neuropharmacoloby
(1984) - et al.
Autoradiographic characterization of [3H]imipramine and [3H]citalopram binding in rat and human brain: species differences and relationships to serotonin innervation patters
Brain Res
(1992) - et al.
Is platelet imipramine binding reduced in depression? a meta-analysis
Biol Psychiatry
(1994) - et al.
A common binding site for tricyclic and nontricyclic 5-hydroxtryptamine uptake inhibitors at the substrate recognition site of the neuronal sodium-dependent 5-hydroxytryptamine
Biochem Pharmacol
(1989) - et al.
Brain 5-HT uptake sites, labelled with [3H]paroxetine, in antidepressant-free depressed suicides
Brain Res
(1990) - et al.
Symmetrical hemispheric distribution of [3H]paroxetine in post mortem human brain from controls and suicides
Biol Psychiatry
(1990) - et al.
Regional brain expression of serotonin transporter mRNA and its regulation by reuptake inhibiting antidepressants
Mol Brain Res
(1993)
Low cerebrospinal fluid 5-HIAA concentration differentiates impulsive from nonimpulsive violent behavior
Life Sci
Cocaine use increases [3H]WIN 35428 binding sites in human striatum
Brain Res
Serotonin transporter mRNA in rat brain is regulated by classical antidepressants
Biol Psychiatry
Human brain receptor alterations in suicide victims
Pharmacol Biochem Behav
Neurotransmitter and neuromodulatory mechanisms involved in alcohol abuse and alcoholism
Neurochem Int
Serotonergic mechanisms in brains of suicide victims
Brain Res
Antidepressive drugs can change the affinity of [3H]imipramine and [3H]paroxetine binding to platelet and neuronal membranes
Eur J Pharmacol
Thermodynamics of the interactions of tricyclic drugs with binding sites for [3H]imipramine in mouse cerebral cortex
Biochem Pharmacol
Neurotransmitter transporters: Recent progress
Ann Rev Neurosci
Unaltered number of brain serotonin uptake sites in suicide victims
J Psychopharmacol
Expression of serotonin transporter messenger RNA in the human brain
J Neurochem
High affinity binding of [125I]RTI-55 to dopamine and serotonin transporters in rat brain
Synapse
p1B15: a cDNA clone of the rat mRNA encoding cyclophilin
DNA
Selective labeling of serotonin uptake sites in rat brain by [3H]citalopram contrasted to labeling of multiple sites by [3H]imipramine
J Pharmacol Exp Ther
The Human Hippocampus
Platelets 3H 5-HT uptake in descendants from alcoholic patients: a potential risk factor for alcohol dependence
Life Sci
Cited by (69)
Hippocampal neuropathology in suicide: Gaps in our knowledge and opportunities for a breakthrough
2022, Neuroscience and Biobehavioral ReviewsCitation Excerpt :It is widely accepted that an overall downregulation of the 5-HT1A system is characteristic for depression (Yohn et al., 2017), without an influence of suicide (López et al., 1998). Where the concentrations of 5-HT and its turnover and transporter were not altered by suicidality (Anisman et al., 2008; Cheetham et al., 1989; Little et al., 1997), its main metabolite, i.e. 5-hydroxyindoleacetic acid, was increased in the HC of depressed patients who died by suicide (Cheetham et al., 1989; Owen et al., 1986). Also, 5-HT2AR is abundant in the HC of patients who completed suicide.
Serotonin transporter gene expression predicts the worsening of suicidal ideation and suicide attempts along a long-term follow-up of a Major Depressive Episode
2018, European NeuropsychopharmacologyCitation Excerpt :Post mortem studies revealed a decreased concentration of the 5-HTT protein in the prefrontal cortex, the hypothalamus and the brainstem of depressed patients died by suicide compared to matched controls (Purselle and Nemeroff, 2003; Stanley et al., 1982). In this context, some authors have also compared the expression levels of SLC6A4 mRNA in post mortem brains between suicide completer and healthy-matched control samples, without showing any difference (Arango et al., 2001; Little et al., 1997; Perroud et al., 2010). By quantifying regional brain 5-HTT binding in vivo using PET, Miller et al. (2013) reported that depressed suicide attempters had lower 5-HTT binding in midbrain compared with depressed non-attempters and healthy controls.
The serotonin transporter in psychiatric disorders: Insights from PET imaging
2015, The Lancet PsychiatryAddictive Disorders
2013, Emery and Rimoin's Principles and Practice of Medical GeneticsThe Genetic Basis of Addictive Disorders
2012, Psychiatric Clinics of North AmericaCitation Excerpt :Further, there is a relatively common, functional A > G single-nucleotide polymorphism (SNP) within the L allele,86 the LG allele being equivalent to the S allele in transcriptional efficiency.86 Further supporting the functional effect of HTTLPR, this locus has been shown to regulate serotonin transporter expression in postmortem brain87 and in vivo using single-photon emission computed tomography (SPECT) imaging88 although not in all studies.89 Low-transcribing HTTLPR genotypes have been inconsistently associated with anxiety, depression, and alcoholism.
The relationship between serotonin transporter gene promoter polymorphism and serum lipid levels at young age in a longitudinal population-representative study
2011, Progress in Neuro-Psychopharmacology and Biological Psychiatry
This work was partially supported by NIH award DA09491.