Elsevier

Biological Psychiatry

Volume 44, Issue 7, 1 October 1998, Pages 526-533
Biological Psychiatry

Review Articles
Antidepressant treatments in the 21st century

This work was presented at the Neuroscience Discussion Forum “A Decade of Serotonin Research” held at Amelia Island, Florida in November 1997. The conference was sponsored by the Society of Biological Psychiatry through an unrestricted educational grant provided by Eli Lilly and Company.
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Abstract

The goal of this review is to provide a provocative discussion of the status of antidepressant treatments in the next century. The first part of the review evaluates the progress (or lack of progress) made in antidepressant medications since the 1950s, when the first chemical antidepressants were discovered by serendipity. The second part then attempts to predict what may be needed to accomplish greater progress in the future, and outlines the types of approaches that could be used to develop truly novel, and more effective, treatments of depression.

Keywords

Antidepressants
stress
G Protein coupled receptors
intracellular messengers
neurotrophins
trk receptors

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Preparation of this review was supported by grants from the National Institute of Mental Health and by the Abraham Ribicoff Research Facilities of the Connecticut Mental Health Center.