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2022, Neuroscience and Biobehavioral ReviewsCitation Excerpt :The first began with the synthesis of organic dyes, particularly the fabric dye, methylene blue (MB). Several excellent reviews cover the developments of MB (Howland, 2016a; b; Schirmer et al., 2011), phenothiazines (Frankenburg and Baldessarini, 2008; López-Muñoz et al., 2005; Ohlow and Moosmann, 2011) and antipsychotics starting with the first phenothiazine antipsychotic, chlorpromazine (Frankenburg and Baldessarini, 2008; López-Muñoz et al., 2005; Shen, 1999). Schirmer et al. (Schirmer et al., 2011) describe MB as the first synthetic drug in medical history beginning with its use in treating malaria in 1891 after MB’s synthesis in 1876 by Heinrich Caro (1834–1910) (Frankenburg and Baldessarini, 2008).
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