Serotonin receptors: Clinical implications
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Cited by (203)
The serotonin 2C receptor agonist WAY-163909 attenuates ketamine-induced hypothermia in mice
2019, European Journal of PharmacologyCitation Excerpt :5-HT2C receptors are the most abundantly expressed serotonin receptor in the hypothalamus (Yadav et al., 2009). 5-HT2 receptors have been reported to increase vasoconstriction in the viscera and skin (Glennon, 1990). Previous studies have linked the 5-HT2A receptor to thermoregulation (Ootsuka and Blessing, 2006; Pawlyk et al., 2006; Sipe et al., 2004).
Design, synthesis and pharmacological evaluation of some novel derivatives of 1-{[3-(furan-2-yl)-5-phenyl-4,5-dihydro-1,2-oxazol-4-yl]methyl}-4-methyl piperazine
2017, Arabian Journal of ChemistryCitation Excerpt :In addition, anxiety and depression are conceived to be different neuropsychiatric diseases, there is considerable overlap among the clinical symptoms of these disorders and differential diagnosis is often difficult (Tyrer, 1992). Anxiety often coexists with depression or may precede the development of depressive symptoms (Nutt and Glue, 1989) and anxiety and depression may be biochemically colligated since there are many similarities in the neurological substrates thought to play a role in these diseases, (Glennon and Dukat, 1995; Heninger, 1995; Sleight et al., 1991; Siever et al., 1991; Perregaard et al., 1993; Glennon, 1990; Zifa and Fillion, 1992) including a recent report describing a polymorphism in the serotonin transporter gene associated with both anxiety and depression-related personality traits (Lesch, 1998). In accession, anxiolytic agents may have utility in treating depression, (Charney et al., 1990) and there is developing clinical evidence that antidepressants may be effective in treating generalized anxiety disorder (Rickels et al., 1993).
The anxiogenic-like effects of dehydration in a semi-desert rodent Meriones shawi indicating the possible involvement of the serotoninergic system
2012, Acta HistochemicaCitation Excerpt :In addition, the implication of serotonin 2A receptors has been shown in some types of anxiety disorders, especially panic disorders (Ho-Kyoung et al., 2008), and a significant association between the severity of the panic symptoms and the serotonin 2A receptor gene has been reported (Ho-Kyoung et al., 2008). Nevertheless, there are many controversies about the exact role of 5-HT in anxiety (Glennon, 1990; Handley, 1995). Several authors have demonstrated that reduction in 5-HT neurotransmission decreases anxiety, whereas stimulation of the 5-HT system results in an anxiogenic effect (Dumuis et al., 1988; Charney et al., 1990; Lucki, 1992).
Cocaine-induced genital reflexes in paradoxical sleep deprived rats: Indications of mediation by serotonin receptors
2007, Progress in Neuro-Psychopharmacology and Biological Psychiatry[<sup>18</sup>F]MPPF as a tool for the in vivo imaging of 5-HT<inf>1A</inf> receptors in animal and human brain
2007, NeuropharmacologyCitation Excerpt :In this context, some discrepancies between postmortem studies of human brain could potentially be resolved with [18F]MPPF PET imaging studies in vivo. As already mentioned, 5-HT1A receptors are implicated in a number of CNS diseases, including psychiatric disorders, such as depression, anxiety and schizophrenia (Kostowski et al., 1989; Glennon, 1990; Saudou and Hen, 1994; Peroutka, 1995; Saxena, 1995). As an [18F]MPPF PET database of healthy subjects has only been recently available, no clinical study has yet been published at this time with these types of patients.