Increase in Immune Activation, Vascular Endothelial Growth Factor and Erythropoietin after an Ultramarathon Run at Moderate Altitude
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2020, Journal of Science and Medicine in SportCitation Excerpt :Neopterin was measured in plasma (n = 5), serum (n = 4) and urine (n = 2, one study measured plasma and urine neopterin) from predominantly highly trained individuals. The response of neopterin was measured prior to and following long distance running events spanning from 20 km under two hours26 to ultramarathons (67 km) at moderate altitude.27 Independent of bio-fluid, neopterin significantly increased in response to running in eight of the nine studies.
Reduction of hemoglobin, not iron, inhibited maturation of red blood cells in male rats exposed to high intensity endurance exercises
2019, Journal of Trace Elements in Medicine and BiologyCitation Excerpt :We also noticed that serum erythropoietin contents increased in running rats but unchanged in swimming rats. It was possibly induced by acute RBCs destructions resulted from running, which producing more impacts on body than swimming [34–36]. In the case that iron was not the cause of hemoglobin reduction and RBCs immaturation, we evaluated status of protein nutrition because protein was another part of hemoglobin except iron.
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2018, Molecular Aspects of MedicineDifferential effects of voluntary wheel running and toy rotation on the mRNA expression of neurotrophic factors and FKBP5 in a post-traumatic stress disorder rat model with the shuttle-box task
2018, Biochemical and Biophysical Research CommunicationsCitation Excerpt :In the EE group, amygdalar NGF and VEGF showed higher expression than in the other three groups; thus, both the RW and toy components may be necessary to increase amygdalar NGF and VEGF. Previous studies showed that NGF and VEGF are involved in neuronal plasticity [24–26], and the amygdala plays a central role in the pathology of PTSD [27]. Therefore, the effect of EE on PTSD-like behavior might be mediated through amygdalar NGF and VEGF.
Joggin’ the Noggin: Towards a Physiological Understanding of Exercise-Induced Cognitive Benefits
2018, Neuroscience and Biobehavioral ReviewsCitation Excerpt :In mice, exercise induces expression of VEGF in the hippocampus (Morland et al. 2017; Tang et al. 2010) as well as the lungs and locomotor skeletal muscles, though increased expression is exclusive to the hippocampus in hypoxic conditions (Tang et al. 2010). In humans, exercise at high altitudes has been observed to increase serum VEGF levels immediately after exercise, with elevated levels lasting up to one month after training (Asano et al. 1998; Schobersberger et al. 2000). Finally, exercise appears to increase the permeability of the human blood-brain barrier (BBB) (Bailey et al. 2011), which could also contribute to the aforementioned effects.
An acute bout of aerobic or strength exercise specifically modifies circulating exerkine levels and neurocognitive functions in elderly individuals with mild cognitive impairment
2018, NeuroImage: ClinicalCitation Excerpt :Indeed, Voss et al. (2013) demonstrated that exercise-induced changes in circulating growth factors (e.g., BDNF, IGF-1, and VEGF) were related to increases in temporal lobe functional brain connectivity in the elderly. Acute exercise can increase circulating BDNF, IGF-1 and VEGF in healthy persons (Bang et al., 1990; Correia et al., 2010; Rojas Vega et al., 2010; Schobersberger et al., 2000). In animal studies, FGF-2 expression can be regulated by short-term physical exercise to enhance cognitive function (Gomez-Pinilla et al., 1997, 1998).
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Wolfgang Schobersberger, MD, Division for General and Surgical Intensive Care Medicine, Department for Anesthesia and Intensive Care Medicine, Anichstrasse 35, A - 6020 Innsbruck, Austria. Phone: #43-512-504-4560, Fax: #43-512-504-2749