Progress in Neuro-Psychopharmacology and Biological Psychiatry
Full length original paper clinical studyAbnormal cerebral perfusion in chronic methamphetamine abusers: A study using 99mTC-HMPAO and spect
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Fluoroethoxy-1,4-diphenethylpiperidine and piperazine derivatives: Potent and selective inhibitors of [<sup>3</sup>H]dopamine uptake at the vesicular monoamine transporter-2
2017, Bioorganic and Medicinal Chemistry Letters1,4-Diphenalkylpiperidines: A new scaffold for the design of potent inhibitors of the vesicular monoamine transporter-2
2016, Bioorganic and Medicinal Chemistry LettersAbnormal reward functioning across substance use disorders and major depressive disorder: Considering reward as a transdiagnostic mechanism
2015, International Journal of PsychophysiologyCitation Excerpt :SUDs are associated with neural adaptations that occur in response to and withdrawal from substances. In both animal and human models, acute and chronic responses to substances lead to a reduction in brain dopamine and alterations to a number of brain regions (e.g., ventral cingulate gyrus, involved in mood regulation; prefrontal cortex, involved in executive functioning; ventral striatum, involved in reward processing; thalamus, involved in arousal; Gouzoulis-Mayfrank et al., 1999; Iyo et al., 1997; Sapolsky, 2003; Volkow et al., 2001a, 2001b). In addition to the neuronal changes in response to substance administration, changes in the brain's reward circuitry and in the amygdala have been implicated in inducing the negative emotional symptoms that often occur during early phases of withdrawal (Philibin et al., 2011).
Methamphetamine use: A comprehensive review of molecular, preclinical and clinical findings
2013, Drug and Alcohol DependenceCitation Excerpt :Binge users may exhibit highly focused and repetitive behaviors, known as “punding” (Fasano et al., 2008), such as the stereotyped handling and sorting of objects. Particular attention has been paid to the capacity of high and sustained doses of MA to cause psychological changes that resemble the symptoms of psychosis (Barr et al., 2006), although it is important to note that relatively few studies have observed this effect in people using only MA, and with no prior history of mental illness (Iwanami et al., 1994; Iyo et al., 1997, 2004). Binge-like use of MA has been reported to induce sleeplessness, hallucinations and paranoia (Leamon et al., 2010), which may be associated with irritability and unprovoked aggression (Payer et al., 2011).
Methamphetamine causes sustained depression in cerebral blood flow
2011, Brain ResearchCitation Excerpt :The use of amphetamines, such as MA, is associated with cerebrovascular complications such as cerebrovascular accidents (CVA) (Perez et al., 1999; Westover et al., 2007; Yen et al., 1994), hemorrhage (Delaney and Estes, 1980; Westover et al., 2007), hypoxic damage (Kaye et al., 2008) and vasculitis (Salanova and Taubner, 1984). Interestingly, while changes to cerebral blood flow (CBF) in response to acute amphetamine exposure have been reported (Devous et al., 2001; Rose et al., 2006), there is evidence of long-term effects on CBF from MA use even in abstinent users (Chang et al., 2002; Hwang et al., 2006; Iyo et al., 1997), suggesting that the effect of MA on CBF is at least partially irreversible. Reports on the effect of MA on global or focal CBF are controversial and incomplete as seen by the variation in published data.
In vivo evidence for long-term CNS toxicity, associated with chronic binge use of methamphetamine
2010, Drug and Alcohol Dependence
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Present address: Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu-shi, Japan.