The effects of diazepam on sensory gating in healthy volunteers
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Effects of melatonin on prepulse inhibition, habituation and sensitization of the human startle reflex in healthy volunteers
2014, Psychiatry ResearchCitation Excerpt :This result is likely to be attributable to the sedative and anxiolytic actions of the hormone, as the startle response is known to be potentiated by fear and or anxiety (Davis, 1993). Various other sedative compounds, such as benzodiazepines (Abduljawad et al., 1997; van Luijtelaar, 2003) but also the atypical antipsychotics clozapine (Graham et al., 2001) and quetiapine (Graham et al., 2004), have demonstrated to reduce raw startle amplitudes in healthy subjects, whereas opposite effects were observed with the anxiogenics amphetamine (Davis et al., 1975; Swerdlow et al., 1990) and yohimbine (Davis and Astrachan, 1981; Morgan et al., 1993). Alternatively as stated above, melatonin increases D1/D2 activity but decreases noradrenergic activity.
Hallucinations and negative symptoms differentially revealed by frontal and temporal responses to speech in schizophrenia
2014, Schizophrenia ResearchCitation Excerpt :The difference could not be attributed to treatment received by the patients. Indeed, benzodiazepines and neuroleptics have been reported to have no effect on the characteristics of P1 (Moxon et al., 2003; van Luijtelaar, 2003). The auditory P1 or P50 is the first positive deflection of the auditory ERPs recorded at fronto-central sites.
Impaired P50 suppression in fear extinction in obsessive-compulsive disorder
2010, Progress in Neuro-Psychopharmacology and Biological PsychiatryTowards a functional topography of sensory gating areas: Invasive P50 recording and electrical stimulation mapping in epilepsy surgery candidates
2007, Psychiatry Research - NeuroimagingCitation Excerpt :However, in a recent surface study from our group comparing patients with focal lobe epilepsy to healthy controls (Boutros et al., 2006), P50 auditory gating did not differ significantly between the groups. As for effects of drug treatment, to the best of our knowledge, there is only one study examining the effects of anticonvulsant agents on P50 sensory gating (Van Luijtelaar, 2003). In that study, application of a single dose of diazepam to healthy individuals did not alter P50 gating.
P50 sensory gating in panic disorder
2006, Journal of Psychiatric Research