Letter to NeuroscienceImipramine and phenelzine decrease glutamate overflow in the prefrontal cortex—a possible mechanism of neuroprotection in major depression?
Section snippets
Materials
l-Glutamate, l-aspartate and β-mercaptoethanol were from Sigma (Poole, UK). Acetonitrile, sodium acetate trihydrate and di-sodium tetraborate were purchased from B.D.H. Laboratory Supplies (Lutterworth, Leicestershire, UK). o-Phthalaldehyde was from Aldrich (Gillingham, Dorset, UK).
Amino acid outflow in slices
Male Wistar rats (200–250 g) were used throughout. All efforts were made to minimize the number of animals used, and experiments were carried out in conformity with the 1986 UK Animals (Scientific Procedures) Act. For
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