Original articleApoptosis Detected in the Amygdala Following Myocardial Infarction in the Rat
Section snippets
Methods and Materials
Forty-seven Sprague–Dawley rats (Charles River Canada, Saint-Constant, Québec) weighing 300–350 g were included in this study. All procedures were in accordance with the rules of the Canadian Council on Animal Care.
Infarct Size
In our experimental model, infarct size in the MI group was 54% ± 2% of the area at risk (n = 17) and 50% ± 2% for the MI+PTX group (n = 9; p = .2059 vs. MI only). The area at risk represents around 50% of left ventricle. Number of Sham rats was 14 and 7 for the Sham + PTX.
PI3K Activity
Activity of PI3K observed in the amygdala was significantly decreased in the MI group (36% ± 10%) as compared with the Sham group (Figure 1A). This effect is completely blocked in MI+PTX group (3.6% ± 3.4% of Sham). No
Discussion
The amygdala is a key component of the limbic system and has been associated with emotional, motivational, and homeostatic components of MDD (Nieuwenhuys 1996). The amygdala maintains connections with other brain areas, including the hippocampus, thalamus, neocortex, striatum, and basal forebrain. The amygdala is also involved in the regulation of cardiovascular functions mainly by modulation of neuronal activity including the autonomic parasympathetic level and the baroreceptor reflex arc (Ter
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