Brief reportWhite-Matter Integrity Predicts Stroop Performance in Patients with Geriatric Depression
Section snippets
Participants
Participants were depressed patients aged 60 to 86 years who were recruited at a university-based geriatric psychiatry clinic. All participants signed informed consent. Participants met DSM-IV criteria (American Psychiatric Association 1994) for unipolar major depression and had a score of >18 on the 24-item Hamilton Depression Rating Scale (HDRS; Williams 1988). Exclusion criteria included the following: (1) history of psychiatric disorders (except personality disorders) before the onset of
Results
Significant positive correlations between CWI scores and FA after partialing out age were noted in multiple regions, including white matter lateral to the anterior and posterior cingulate cortex, left prefrontal white matter, and white matter in insular, posterior temporal, parahippocampal, and occipital regions (Figure 1A; Table 2). To examine the specificity of the CWI correlations, we examined frontal regions in which significant relationships remained between FA and CWI, after partialing
Discussion
The main finding of this study is that reduced FA in frontostriatal-limbic regions is associated with poor response inhibition on the Stroop in depressed older patients. These findings are consistent with imaging studies that implicate the anterior cingulate and dorsolateral prefrontal cortex in Stroop performance in healthy subjects (e.g., Leung et al 2000, MacDonald et al 2000, Pardo et al 1990). To our knowledge, this is the first study to use a voxelwise analysis of FA to identify
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