Original articleRegional Gray Matter Volume Abnormalities in the At Risk Mental State
Section snippets
Participants
The MRI data were collected as part of a research program (Prediction and early detection of schizophrenia - a prospective multilevel approach), supported by the Swiss National Science Foundation (No. 3200-057216-99; 3200-057216/3) that has been described in detail elsewhere (Riecher-Rössler et al, in press).
Subjects with an ARMS and patients experiencing their FE of psychosis were recruited through a specialized clinic for the early detection of psychosis at the Psychiatric Outpatient
Clinical Follow-up of High Risk Subjects
The mean duration of follow-up of all ARMS subjects was 25 months (median 23 months). Twelve of the 35 ARMS subjects (34%) developed a psychosis subsequent to being scanned (ARMS-T). The mean duration of follow up in this subgroup was 306 days (range, 25–1137 days). Ten of the transitions to psychosis occurred during the first year of follow-up, with one in the second year and one in the fourth. All the subjects who developed a psychosis met OPCRIT criteria for schizophrenia when re-assessed 12
Discussion
Our first prediction, that individuals with an ARMS would show volumetric deficits qualitatively similar to those seen in first episode psychosis was confirmed. The ARMS group had smaller gray matter volumes in a cluster that included the left insula and adjacent parts of the superior temporal gyrus and in a midline region that included the posterior cingulate gyrus and precuneus. There was also a trend for smaller volumes in the left parahippocampal gyrus, hippocampus and amygdala, and a
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