Original ArticleBrain-Derived Neurotrophic Factor Val66Met and Psychiatric Disorders: Meta-Analysis of Case-Control Studies Confirm Association to Substance-Related Disorders, Eating Disorders, and Schizophrenia
Section snippets
Search Strategy
The Medline database was searched using the PubMed search engine. This database was searched from the first date available up to May 17, 2006, using as a first step the following combination of key words: polymorph* AND (bdnf or brain derived), mutation AND (bdnf or brain derived), variant* AND (bdnf or brain derived), associat* AND (bdnf or brain derived), and SNP AND (bdnf or brain derived). In a second step, the key word “bdnf” was also combined with mood, schizophrenia, anxiety, eating, and
Results
A total of 78 articles on studies of BDNF and psychiatric disorders conducted in 14 countries and published by May 17, 2006, were identified from applying our search strategies. On selection, 43 did not meet one or more of the inclusion criteria (see Supplement 1 for detailed information) and 35 met the inclusion criteria and were studied in this meta-analysis (Table 1). Some of these articles contributed more than one study to the meta-analysis (de Krom et al 2005, Jiang et al 2005,
Discussion
This meta-analysis includes data from 39 case-control studies and 5 psychiatric phenotypes: eating disorders, substance-related disorders, mood disorders (subdivided into major depression disorders and bipolar disorders), and schizophrenia.
Large differences in the allelic frequencies for the BDNF Val66Met polymorphism between populations of different ethnic origins have previously been reported with similar results (Shimizu et al. 2004) and also coincide with the frequencies found in public
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