Original ArticleTemporal Lobe Dysfunction in Medication-Naïve Boys With Attention-Deficit/Hyperactivity Disorder During Attention Allocation and Its Relation to Response Variability
Section snippets
Subjects
Patients were 17 right-handed male adolescents, in the age range from 9 to 16 years, recruited from parent support groups, clinics, and advertisement. Clinical diagnosis of combined subtype of ADHD (DSM IV) (24) was established through interviews with a trained psychiatrist with the standardized Maudsley diagnostic interview (25), which includes a systematic symptom checklist excluding autism and other pervasive developmental disorders, bipolar disorder, and affective and anxiety disorders.
Task Performance
As expected, patients with ADHD compared with control adolescents showed increased variability of response to both standard and oddball trials (Table 2). This difference was more pronounced during standard trials. Consequently, the between-group ANOVAs were co-varied for the combined intra-subject–SD to standard and oddball trials. Within each group and across groups, the intra-subject variability of response was highly correlated with reaction times (r > .7, p < .004). Consequently, all
Discussion
Medication-naïve patients with ADHD had no specific deficits related to the oddball condition but, as expected, showed increased response variability during both standard and oddball conditions. During the oddball versus standard contrast, patients with ADHD compared with control subjects showed reduced brain activation in left and right superior and middle temporal cortices reaching subcortically into bilateral insula and right basal ganglia and bordering the inferior parietal lobes in the
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