Original ArticleAnterior Cingulate Cortex and Benefit of Predictive Cueing on Response Inhibition in Stimulant Dependent Individuals
Section snippets
Participants
Nineteen MD individuals (17 male) and 19 age- and education-matched HC subjects (16 male) participated in the study, performing the go/nogo task during functional magnetic resonance imaging (fMRI). The MD participants were all treatment-seeking and met criteria for current dependence on methamphetamine as assessed by a psychiatrist, psychologist, or trained research assistant using the Structured Clinical Interview for DSM-IV (22). All MD individuals had voluntarily entered and completed a
Demographics
There were no significant differences in age, education, NART errors, handedness, race, or gender between the two groups (Table 1).
Task Performance
There were no differences between MD and HC groups on hit rate, beta, or d’ (Table 1). The groups did not differ on the number of false alarms (F (1,36) = 1.90; p = .176), but there was a trend toward an effect of Previous Trial (F (1,36) = 3.63; p = .065) and a significant Group × Previous Trial interaction (F (1,36) = 4.59; p = .04). Follow-up t tests revealed
Discussion
There are two main findings of this investigation: first, MD subjects showed ACC activation in response to cues predicting the need to inhibit responses in a go/nogo task; second, the more MD individuals’ ACCs were activated by such cues the better inhibitory performance was on trials following the cues. There was no cue-related ACC activation in HC subjects, possibly because cueing made no difference to their FA rate, which was low in both cases (∼7%). Methamphetamine dependent subjects, on
References (29)
- et al.
Deficits in response inhibition associated with chronic methamphetamine abuse
Drug Alcohol Dep
(2005) - et al.
Impaired inhibitory control of behavior in chronic cocaine users
Drug Alcohol Dep
(2002) - et al.
Low N-acetyl-aspartate and high choline in the anterior cingulum of recently abstinent methamphetamine-dependent subjects: A preliminary proton MRS study
Psychiatr Res Neuroimag
(2002) - et al.
Decreased cerebral blood flow of the right anterior cingulate cortex in long-term and short-term abstinent methamphetamine users
Drug Alcohol Dep
(2006) - et al.
Decision making by methamphetamine-dependent subjects is associated with error-rate-independent decrease in prefrontal and parietal activation
Biol Psychiatry
(2003) - et al.
Individuals with schizophrenia present hypo- and hyperactivation during implicit cueing in an inhibitory task
Neuroimage
(2006) - et al.
Effects of Preliminary Information in A Go Versus No-Go Task
Acta Psychologica
(1991) - et al.
Mapping motor inhibition: Conjunctive brain activations across different versions of go/no-go and stop tasks
Neuroimage
(2001) AFNI: software for analysis and visualization of functional magnetic resonance neuroimages
Compu Biomed Res
(1996)- et al.
Cognitive and emotional influences in anterior cingulate cortex
Trend Cogn Sci
(2000)
An empirical investigation into the number of subjects required for an event-related fMRI study
Neuroimage
Implications of chronic methamphetamine use: A literature review
Harv Rev Psychiatry
Diagnostic and statistical manual of mental disorders
On the Ability to Inhibit Thought and Action—A Theory of An Act of Control
Psychol Rev
Cited by (44)
Impaired proactive control in individuals with methamphetamine use disorder: Evidence from ERPs
2023, Journal of Psychiatric ResearchSustained attention alterations in major depressive disorder: A review of fMRI studies employing Go/No-Go and CPT tasks
2022, Journal of Affective DisordersCitation Excerpt :The ACC seems to subserve multiple complex processes in task execution (Dosenbach et al., 2008; Simmonds et al., 2008) and to be associated with a complex network subsiding response inhibition, particularly involved in the No-Go condition (Criaud and Boulinguez, 2013; Nixon et al., 2013; Rubia et al., 2001; Swick et al., 2011). In particular, specific functions attributed to the ACC also include error detection and involvement in response conflict resolution (Botvinick et al., 1999; Brown and Braver, 2005; Carter et al., 1998; Leland et al., 2008; Magno, 2006). Given its multiple and complex roles, its behavior during tasks is often biphasic, and is possibly associated to the differential involvement of its subcomponents in the diverse and seemingly conflicting cognitive processes activated by the exercise (Rubia et al., 2001).
Inhibitory-control training for cocaine use disorder and contingency management for clinic attendance: A randomized pilot study of feasibility, acceptability and initial efficacy
2020, Drug and Alcohol DependenceCitation Excerpt :Stop-signal reaction time (i.e., latency to inhibit an initiated motor response) was significantly longer for methamphetamine abusers, suggesting that methamphetamine use is associated with a specific deficit in inhibiting a pre-potent response. Other investigators systematically replicated these findings in human laboratory studies and preclinical experiments (Furlong et al., 2016; Leland et al., 2008; Tabibnia et al., 2011; Tolliver et al., 2012, cf. van der Plas et al., 2009). Whether inhibitory-control training alone or combined with an intervention that targets another facet of impulsivity would effectively reduce methamphetamine use remains to be determined.
Goal-based interventions for executive dysfunction in addiction treatment
2020, Cognition and Addiction: A Researcher's Guide from Mechanisms Towards InterventionsMethamphetamine use and cognitive function: A systematic review of neuroimaging research
2019, Drug and Alcohol DependenceCitation Excerpt :One study was conducted in abstinent subjects (Leland et al., 2008) and the other study was conducted in active-users (Jan et al., 2012b). Abstinent MA subjects made more errors on the task but performed comparably to controls on the trials preceded by cues (Leland et al., 2008). In addition, MA subjects activated the ventral ACC in response to the predictive cues and this activation was positively associated with performance.