Archival Reportγ-Band Auditory Steady-State Responses Are Impaired in First Episode Psychosis
Section snippets
Subjects
This study was approved by the McLean Hospital Institutional Review Board. After complete description of the study to the subjects, written informed consent was obtained.
Subjects were 32 first-episode psychosis patients and 34 healthy control subjects (HC; 14 female) paid for their participation. The HC were recruited from the local community through newspaper advertisements and were free of Axis I or II disorders (Structured Clinical Interview for DSM-III-R Non-Patient Edition [SCID-NP], 15;
Results
The ASSR was maximal—as is typical—for 40-Hz stimulation in both the phase locking and evoked power data (Figure 1). Also, during 20-Hz stimulation a robust harmonic was apparent at 40 Hz.
Discussion
This study demonstrates that the γ ASSR deficit is present at first hospitalization for both schizophrenia and affective disorder, particularly bipolar disorder (we note that the effects reported for the AFF group did not change appreciably when the non-bipolar patients were removed from the analyses). Thus, the γ ASSR deficit that has been observed in chronic psychosis patients does not seem to be due to brain abnormalities that only arise because of the chronic state, although progressive
References (40)
Neuronal synchrony: A versatile code for the definition of relations?
Neuron
(1999)- et al.
Neural synchrony in brain disorders: Relevance for cognitive dysfunctions and pathophysiology
Neuron
(2006) - et al.
Evoked gamma band synchronization and the liability for schizophrenia
Schizophr Res
(2004) - et al.
Gamma band EEG oscillations reveal neural network cortical coherence dysfunction in schizophrenia patients
Biol Psychiatry
(2006) The assessment and analysis of handedness: The Edinburgh inventory
Neuropsychologia
(1971)- et al.
A new method for off-line removal of ocular artifact
Electroencephalogr Clin Neurophysiol
(1983) - et al.
Oscillatory gamma activity in humans and its role in object representation
Trends Cogn Sci
(1999) - et al.
A review of MRI findings in schizophrenia
Schizophr Res
(2001) - et al.
Molecular and cellular mechanisms of altered GAD1/GAD67 expression in schizophrenia and related disorders
Brain Res Rev
(2006) - et al.
GABAergic interneurons: Implications for understanding schizophrenia and bipolar disorder
Neuropsychopharmacol
(2001)
Neurochemical markers for schizophrenia, bipolar disorder, and major depression in postmortem brains
Biol Psychiatry
Reduced oscillatory gamma-band responses in unmedicated schizophrenic patients indicate impaired frontal network processing
Clin Neurophysiol
Cortical inhibitory neurons and schizophrenia
Nat Rev Neurosci
Neural synchrony indexes disordered perception and cognition in schizophrenia
Proc Natl Acad Sci U S A
A 40 Hz auditory potential recorded from the human scalp
Proc Natl Acad Sci U S A
Activation of human cerebral and cerebellar cortex by auditory stimulation at 40 Hz
J Neurosci
EEG synchronization to modulated auditory tones in schizophrenia, schizoaffective disorder, and schizotypal personality disorder
Am J Psychiatry
Gamma frequency-range abnormalities to auditory stimulation in schizophrenia
Arch Gen Psychiatry
Event-related potential abnormalities in bipolar disorder: Relationship to symptoms, medication, and substance disorders
Neural synchronization deficits to auditory stimulation in bipolar disorder
NeuroReport
Cited by (266)
Effects of Memantine on the Auditory Steady-State and Harmonic Responses to 40 Hz Stimulation Across Species
2024, Biological Psychiatry: Cognitive Neuroscience and NeuroimagingThe specificity of the auditory P300 responses and its association with clinical outcomes in youth with psychosis risk syndrome
2024, International Journal of Clinical and Health Psychology40-Hz auditory steady-state response deficits are correlated with the severity of persistent auditory verbal hallucination in patients with schizophrenia
2023, Psychiatry Research - Neuroimaging