Archival ReportImpaired Sensorimotor Gating of the Acoustic Startle Response in the Prodrome of Schizophrenia
Section snippets
Participants
Subjects with symptoms suggestive of either early or late prodromal stages were recruited as described previously (31). In brief, subjects were screened by general practitioners, counseling services or secondary health care providers using the 17-item Early Recognition Inventory/Interview for the Retrospective Assessment of the Onset of Schizophrenia (ERIraos) checklist (31). Persons scoring six points or higher were referred to the Early Recognition and Intervention Center at the Department of
Demographic and Clinical Data
Demographic data and clinical data are shown in Table 1. Multiple and single comparisons with Chi-Square tests revealed no significant differences with respect to sex and smoking, and analysis of variance (ANOVA) showed no significant differences with respect to years of education or verbal IQ between the groups. However, an ANOVA revealed a significant group effect for age (p < .01). LSD post hoc tests showed that both EP and LP were younger than US (p < .05) and MS (p < .01). However, the
Discussion
This study is the first to investigate PPI, habituation, and startle reactivity of the ASR in individuals fulfilling research diagnostic criteria of a psychotic prodrome. The major finding is that prodromal subjects had a significant PPI deficit. This was true for both early and late prodromal subgroups. As expected, we could also demonstrate reduced PPI in unmedicated first-episode schizophrenia patients, whereas medicated schizophrenia patients did not differ from control subjects. Further
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