Archival ReportAn Anterior-to-Posterior Shift in Midline Cortical Activity in Schizophrenia During Self-Reflection
Section snippets
Participants
Nineteen patients with DSM-IV–diagnosed schizophrenia and 20 healthy control subjects were enrolled in the study. Patients with clinically stable schizophrenia, diagnosed using the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID) (22), were recruited and characterized by the MGH Schizophrenia Clinical and Research Program recruitment team. Healthy control subjects were recruited via advertisement. All subjects were right-handed and native speakers of English. The healthy control
Behavior
There were no significant differences between the two groups in response times for the SR (t = .88, df = 33, p = .39) or AL (t = 1.74, df = 33, p = .09) tasks, or in the percentages of trials rated as self-descriptive during the SR blocks (t = .111, df = 33, p = .91), or rated as desirable during the AL blocks (t = .54, df = 33, p = .59). See Table 2 for means and additional behavioral results.
Anatomic ROI analysis (SR or AL vs. a low-level baseline)
In this analysis, a significant Region by Task by Group interaction (F = 3.31; df = 2; p = .04), with
Discussion
In this study, patients with schizophrenia showed abnormally elevated activation of the right and left m/pCC during self-reflection, compared to a low-level baseline and to responses during a nonintrospective task. Also, in a cortical surface-based analysis, the schizophrenia patients showed abnormally reduced responses during self-reflection, compared with a nonintrospective task, within the right ventral mPFC. Lastly, this abnormal pattern of task-dependent activation in schizophrenia was
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